Background

UV radiation is paradoxically the source of concern and of benefit for the human body. Although type B ultra-violet radiation (280 – 315 nm) is increasingly monitored and screened as the cause of erythema-sunburn, premature aging of skin and even skin cancer, natural exposure to sunlight is undeniably responsible for the synthesis of 90% of our vitamin D. Exposure to sunlight is indispensable to the human body as it controls almost 2,000 of 10,000 human genes. Its effect on mineralization is recognized in many processes now beyond bone health. Vitamin D deficiency has been related to a number of chronic conditions and diseases in adults who are not exposed to adequate sunlight.* So what is the right amount of sunlight exposure?

The VITA-D Biodosimeter bioequivalence technology is intended to enable a user to abandon arbitrary rules of thumb and determine more precisely the appropriate sunlight that allows harvesting the sun's benefits while avoiding its threats.

* Vitamin D deficiency is linked to rickets, osteoporosis, and many chronic diseases such as cancer (breast, ovarian, colon and prostate), chronic pain, chronic fatigue, autoimmune diseases (multiple sclerosis, rheumatoid arthritis and Type 1 diabetes), high blood pressure, mental illnesses, heart disease, psoriasis and tuberculosis.

Description

The VITA-D personal biodosimeter technology is designed to measure the vitamin D synthetic capacity of sunlight and/or artificial ultraviolet radiation in-situ, using the same photochemical process from which vitamin D3 is synthesized in human skin.

The innovators envision two embodiments of this technology:

  • Polymer films are doped with molecules of pro-vitamin D and are used as bio-analogue photo-registering elements. The dose measurement is based on changes in the transmission coefficient properties of the film. This can result in a disposable patch and reader technology.
  • Cholesteric liquid crystals (CLC) are doped with molecules of pro-vitamin D and the qualitative dose measurement is based on the color change, and the quantitative dose measurement is based on the shift of the reflection band wavelength. This results in a disposable CLC film and reader technology.
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Advantages

Personal biodosimeters can be portable and affordable. They allow in-situ and direct measurement of vitamin D-synthetic capacity of UV radiation: both sunlight and artificial sources. They can be used by health professionals, users of tanning equipment and health-conscious individuals. Biodosimeters generate measurements based upon the same molecular photochemistry by which Vitamin D is photosynthesized in human skin. Therefore, direct and reliable measurements can be taken in situ and read on the spot.

Potential Applications

  • Reptile care
  • Mushroom growth
  • Protective cream and cosmetics industries
  • Proactive tanning and skin protection for individuals including children and special needs individuals.
  • Monitor structural and chemical breakdown of UV sensitive materials such as certain plastics

Feature

Benefit

In-situ and direct measurement of vitamin D-synthetic capacity of UV radiation Proactive tanning, natural vitamin D synthesis and skin protection
In-situ and direct measurement of vitamin D-synthetic capacity of UV radiation Agnostic measurement of both sunlight and artificial sources.
One embodiment of this technology is a carried out in a polymer film. Possible disposable product.
Development Status

Proof of principle experiments have been conducted and a biodosimeter device has been designed. The color-sensitive strip has also been designed in principle, but materials selections depend on the specific application.

Reference Number
24211
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