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IMPEDE Medical Device for FLC National Excellence in Technology Transfer and Far West Region Outstanding Commercialization Success | 2020

Researchers from LLNL, Santa Clara-based Shape Memory Medical Inc. and Texas A&M University received an FLC regional award for outstanding commercialization success for their IMPEDE Embolization Plug, a medical device that prevents continued blood flow to diseased vessels.

IMPEDE, which has been cleared by the Food and Drug Administration for use in the U.S. and has been cleared for use in Europe. IMPEDE reduces the blood flow through diseased or damaged vessels that can occur in abdominal aortic aneurysm endoleaks, gastric and esophageal varices or blunt trauma.

To date, more than 250 patients have been successfully treated worldwide with IMPEDE for conditions such as deformed arteries, tumor resections (where blood flow has been blocked to tumors) and pelvic congestion syndrome, with no reported adverse effects.

Winners: LLNL employees who have worked on the project include polymer scientist Tom Wilson, biomedical engineer Jennifer Rodriguez, applied optical physicist Ward Small and computational fluid dynamics engineer Jason Ortega.
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CINDER Project for FLC Far West Region Outstanding Partnership | 2019

Researchers from LLNL, the U.S. Department of Veterans Affairs (VA), the U.S. Department of Defense (DoD) and FoxGuard Solutions, were honored by the FLC for an outstanding partnership.

Their project, the CyberSecure Integration of Networked DER (CINDER), integrates an LLNL-developed cyber-risk analysis toolset with Distributed Energy Resources (DERs) that can generate solar power and are deployed at DoD’s White Sands Missile Range and the VA Medical Center facility in Las Vegas.

While the project has showcased how an integrated patch and network analytics/management solution can mitigate risks to the cyber operations of microgrids, the CINDER partnership has demonstrated how stakeholders can accomplish a larger task together than they could achieve alone.

Winners: LLNL employees who worked on CINDER include: Emma Stewart, associate program leader for defense infrastructure; Jovana Helms, associate program leader for civilian cyber; computer scientists Christopher Lawson and Troy Nash; and electrical engineer Jhi-Young Joo. Charity Follett is the team’s Business Development Executive.
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Detection Array for FLC National Technology Transfer | 2019

The Applied Biosystems'™ Axiom™ Microbiome Array (ABAMA) is the commercialized version of LLNL's microarray innovation, the Lawrence Livermore Microbial Detection Array (LLMDA). In 2016, the LLMDA was licensed to Agilent (acquired by Thermo Fisher Scientific) and went on sale the next year. The microarray is the most comprehensive microorganism detection platform built to date and the first high throughput microarray that employs whole genome resolution for identifying all sequenced microbes. When Lawrence Livermore biologists and computer scientists first unveiled the versatile LLMDA in 2010, it could analyze samples for nearly 3,000 bacteria and viruses, all within 24 hours. But it could only analyze four samples a day. With the 96-well ABAMA, the new detection system can analyze 96 samples in three days. Additionally, each of the 96 wells contain about 1.4 million probes, so samples are analyzed by about 132 million probes. The Federal Laboratory Consortium (FLC) Excellence in Technology Transfer Award recognizes the impactful technical work of the research team as well as the dedicated work by IPO technology transfer professionals in transferring the technology for commercialization by industrial partner, Thermo Fisher Scientific.

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Spack Software Package for FLC Far West Region Top Technology Development | 2019

Spack, an easy-to-use, versatile and scalable software package management tool for high-performance computing (HPC) applications, won an FLC regional award for outstanding technology development.

The LLNL-developed technology simplifies and accelerates building and customizing software by automating the build workflow, thus reducing deployment time for large software stacks from weeks to hours. As open-source software, Spack’s original 100 or so packages have blossomed into a library of more than 4,000 and a large and active community of more than 550 contributors regularly adds features and improvements. Spack is used for software deployment on six of the world’s top 10 supercomputers and it has been adopted by several HPC centers and software development communities.

Winners: The Livermore Spack team is led by Todd Gamblin and includes computer scientists Greg Becker, Tamara Dahlgren, Gregory Lee, Matt Legendre and Peter Scheibel. Charity Follett is the team’s IPO Business Development Executive.
Electrochemical Solid-State NOx Detector for FLC Far West Region Outstanding Partnership | 2018

The electrochemical solid-state NOx detector is an accurate, innovative, and affordable emissions sensor for diesel-fueled automobiles. LLNL scientists developed the sensor being commercialized by a Colorado-based company, CoorsTek Sensors. In 2011, the technology was licensed to EmiSense, a venture-backed developer of advanced sensor technologies who engaged with LLNL in a 30-month cooperative research and development agreement (CRADA) to advance the technology. EmiSense further developed the technology's durability, stability and capabilities to be more suitable for commercialization and manufacturing. The electrochemical solid-state detector could be an important step in the development of accurate and affordable emissions sensors for diesel engines in cars, commercial and marine vehicles, locomotives and stationary equipment. The Livermore/CoorsTek nitrogen oxide detector is simple and inexpensive, potentially opening the door to a $2.5 billion industry by 2023, as the regulation of diesel engines continues to expand. In 2014, EmiSense was acquired by CoorsTek Sensors; they expect the technology to hit the market within the next several years.

FemtoProWrite: A Femtosecond Projection Lithography System for FLC Far West Region Outstanding Technology Development | 2018

LLNL working in collaboration with researchers from the Chinese University of Hong Kong, developed a femtosecond projection lithography system (a femtosecond is one quadrillionth of a second). FemtoProWrite is an additive manufacturing (AM) system for the high-speed writing of complex 3D plastic structures with submicron features. AM is used to fabricate 3D structures by enabling fine control of the geometry and material properties of the different building blocks. To perform high-speed AM of 3D structures with submicron features, FemtoProWrite leverages two-photon polymerization (TPP). TPP is a light-directed writing technique in which chemical reactions initiated by light lead to a change in the phase of a material from liquid to solid within a region that is smaller than the light spot. Submicron AM allows this level of control on a scale 100 to 1,000 times finer than a human hair. FemtoProWrite increases the throughput of submicron AM by a factor of at least 35 times without degrading the submicron resolution. Using the fine resolution of submicron AM, the technology has been used in a wide variety of fields to fabricate functional micro- and nanoscale 3D structures for photonic crystals, optical and mechanical metamaterials, micro fluidics, miniaturized optics and flexible electronics.

High-repetition-rate Advanced Petawatt Laser System (HAPLS) for FLC Far West Region Outstanding Commercialization Success | 2018

HAPLS is a new laser system designed and constructed by LLNL's NIF and Photon Science Directorate (NIF). What makes HAPLS unique is its repetition rate and repeatability. It can fire up to 10 times per second and deliver in each of these pulses the peak power of 1 quadrillion watts — an order of magnitude faster than any other high-peak power laser in the world. This high repetition rate translates into photon flux that is important for commercial applications: HAPLS can deliver up to about 1.1 megajoules per hour of petawatt pulses. Furthermore, the high repetition rate allows exploration of new science with unprecedented precision. Under a $52 million agreement with the Czech Republic's European Extreme Light Infrastructure (ELI), Lab researchers developed and constructed the laser system in only three years from concept to product. After an evaluation by an international peer review group, the HAPLS petawatt laser was declared fully integrated and operational at the ELI Beamlines Research Center in Dolní Břežany, Czech Republic in June. The LLNL-Czech partnership was made possible through an Agreement for Commercializing Technology (ACT) — a new technology transfer mechanism piloted by the U.S. Department of Energy in June 2012. LLNL team members included Constantin Haefner, Andy Bayramian, Dan Mason, Jeff Horner, Craig Siders, Genaro Mempin, and Dave Dawes. ELI recognized team members were Roman Hvezda and Bedrich Rus.

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Neodymium-doped Fiber Amplifier and Laser for FLC Far West Region Outstanding Technology Development | 2017

LLNL researchers have taken an important step to address the telecommunications industry's need for a bigger and faster bandwidth for internet users by developing a new type of optical fiber amplifier that could potentially double the information-carrying capacity of fiber-optic cables. LLNL team members who have developed the new fiber amplifier are Jay Dawson, Paul Pax, Mike Messerly, Victor Khitrov, Leily Kiani, Reggie Drachenberg, Graham Allen, Diana Chen, Parker Crist, Nick Schenkel, Matt Cook and Chris Ebbers (now retired).

Polyelectrolyte Enabled Liftoff (PEEL) for FLC Far West Region Outstanding Technology Development | 2017

PEEL is a robust, scalable method of fabricating freestanding polymer films that are larger, stronger and thinner than conventional methods can produce. PEEL is used at the National Ignition Facility for the daily fabrication of membranes as thin as 30 nanometers (billionths of a meter) that serve as compliant, load-bearing elements for laser targets. LLNL team members who worked on PEEL include Salmaan Baxamusa, Tayyab Suratwala, Art Nelson, Michael Stadermann, Philip Miller and Chantel Aracne-Ruddle. Three other researchers include summer interns Maverick Chea and Shuaili Li, along with postdoc William Floyd III, all of whom have left the Lab. Two General Atomics employees, Anatolios Tambazidis and Kelly Youngblood, also aided in the development of PEEL.

LLNL's Environmentally Sound Geothermal Silica Extraction Technology for FLC Far West Region Outstanding Partnership | 2016

LLNL's environmentally sound geothermal silica extraction technology is a method and design for extracting high grade silica for specialty ultra-pure silica products from low grade geothermal fluids. Two start-up companies licensed this technology and understood that combining efforts to demonstrate early stage technology would be more beneficial than competing. These two start-up companies successfully collaborated to demonstrate the technology on a pilot scale. LLNL recognized the potential partnership and supported it in order to increase the likelihood of successful demonstration of an environmentally friendly geothermal technology that makes potable water, and a commercial product from a waste product. The LLNL innovators of the technology are Bill Bourcier and Carol Bruten; the IPO Business Development Executive responsible for the technology transfer licensing is Annemarie Meike.

Wireless Battery Sensing and Failure Eliminator (WiBSAFE) for FLC Far West Region Outstanding Technology Development | 2016

WiBSAFE is a compact, cost-effective, and precise sensing system that wirelessly monitors battery health and controls cell-level balancing of energy storage devices. Ultimately, WiBSAFE can enhance the performance, reliability, and safety of such energy storage systems. The technology development team includes: John Chang, James Zumstein, Jack Kotovsky, Joe Farmer, Noel Peterson, Marianne Ammendolia, Frank Puglia, Greg Moore, Arthur Dobley, Ralph Roark, Ryan Lawrence, Todd Bandhauer, James Kschmitter, Bob Doane and Anne-Marie Meike at LLNL; and industrial partners EaglePicher Technologies/Yardney Division, Colorado State University, and eNow.

Ultrascale Visualization Climate Data Analysis Tools (UV-CDAT) for FLC National Interagency Partnership | 2015

A novel system that enables climate researchers to solve their most complex data analysis and visualization challenges. The UV-CDAT tool is the first system to be successfully designed to run unrelated analysis and visualization tools and techniques while capturing independent workflows for enhancing reproducibility. Developed by LLNL and nine partners; Lawrence Berkeley, Los Alamos and Oak Ridge national laboratories; the National Aeronautics and Space Administration's Goddard Space Flight Center, the National Oceanic and Atmospheric Administration's Earth System Research Laboratory, New York University, the University of Utah, Kitware Inc. and Tech-X Corp. LLNL team: Dean Williams and Wes Bethel.

microTLC | 2014

A team of LLNL chemists from the Lab's Energetic Materials Center and the Forensic Science Center developed a miniaturized, portable, thin-layer chromatography (TLC) kit called the microTLC that can detect and identify unknown materials. Originally developed to identify military explosives, the microTLC has been modified and now can also detect illicit drugs, selected environmentally-sensitive materials and precursors, along with determining the purity of the identified compounds. The detection system was licensed to a small business, Field Forensics Inc., which is located in St. Petersburg, Florida. Field Forensics also licensed an earlier LLNL technology, the Easy Livermore Inspection Test for Explosives (ELITE), which has sold more than 100,000 units. Three Laboratory employees - research scientists John Reynolds and Joe Satcher and Catherine Elizondo, a business development executive within the Lab's Industrial Partnerships Office (IPO) - did the work associated with the technology transfer efforts. The microTLC project was honored by the FLC as an "outstanding commercialization success." The principal applications of the microTLC are for the military monitoring of bulk and residual explosives and for law enforcement to monitor illicit substances such as explosives and drugs. It also could find use in field and laboratory applications for forensics and first responders.

Solution Grown Organic Crystal Scintillators | 2014

Working under a Department of Homeland Security grant, a team of LLNL scientists developed technology to produce large-scale, four-inch, high-optical quality stilbene crystals. Their work, in teaming with an East Coast photonics manufacturer, was recognized as an "outstanding commercialization success." The LLNL solution-grown technology is important because it demonstrates a more scalable and more economical approach for producing stilbene crystals, which have superior properties for detecting fast neutrons. Detecting neutrons is a critical capability for identifying special nuclear materials like plutonium in homeland security applications, as well as for uses in research and radiation protection. The stilbene crystal growth technology has been licensed to Inrad Optics, a New Jersey photonics manufacturer and small business. The company also concluded a work-for-others agreement with LLNL to assemble solution-growth equipment. In June, Inrad Optics won two awards for its development of nuclear detection material licensed from LLNL. It was recognized by the Domestic Nuclear Detection Office for exceptional contributions to advanced materials development for neutron detection of nuclear materials. And the firm was named one of 25 companies to receive the Tibbetts Award from the U.S. Small Business Association for playing a critical role in research and development for the government. Five LLNL employees -- Elizondo and research scientists Natalia Zaitseva, Steve Payne, Nerine Cherepy and Leslie Carman -- worked on the technology transfer efforts with Inrad Optics.

Ultrascale Visualization Climate Data Analysis Tools (UV-CDAT) | 2014

A partnership across government, academic and private sectors has created a novel system that enables climate researchers to solve their most complex data analysis and visualization challenges. The team's work was recognized by the FLC as "outstanding partnership." With the Ultrascale Visualization Climate Data Analysis Tools (UV-CDAT), the software development team has achieved something that has never before been attempted, much less completed, at this level of software engineering for the climate community: the integration of more than 70 disparate scientific software packages and libraries for large-scale data analysis and visualization. The partnership that brought UV-CDAT to life consists of LLNL; Lawrence Berkeley, Los Alamos and Oak Ridge national laboratories; the National Aeronautics and Space Administration's Goddard Space Flight Center, the National Oceanic and Atmospheric Administrations' Earth System Research Laboratory, New York University, the University of Utah, Kitware Inc. and Tech-X Corp.

Digital PCR Technology commercialized | 2013

In 2008, a Pleasanton, Calif. start-up company called QuantaLife licensed an LLNL technology, digital polymerase chain reaction, a refinement of real-time PCR, that allows researchers to quantify and amplify nucleic acids, including DNA and RNA. LLNL Business Development Executive (BDE) Catherine Elizondo and former BDE Ida Shum worked with LLNL researchers and QuantaLife to negotiate and manage the license agreement and business relationships. The work of the Lab's Industrial Partnerships Office, QuantaLife and its successor company was tapped as an "outstanding commercialization success." The founder of QuantaLife and the co-inventor of the technology is a former LLNL employee, Bill Colston. As QuantaLife's CEO, Colston raised multiple rounds of private funding and grew the company from four founders in 2008 to more than 60 employees by 2011. The company was unanimously selected as the "most promising company" at the Personalized Medicine World Conference in 2010. QuantaLife commercialized the Droplet Digital(TM) Polymer Chain Reaction (ddPCR) system, the most accurate genetic analysis platform available. QuantaLife's products drew the attention of Bio-Rad, headquartered in Hercules, Calif. In 2011, Bio-Rad acquired QuantaLife and its assets for $162 million in cash and future milestone payments.

DNA Tagged Reagents for Aerosol Experiments (DNATrax) | 2013

, can be used to reliably and rapidly diagnose airflow patterns and problems in both indoor and outdoor venues. This work won an "outstanding technology development" award. Until DNATrax particles were developed, no rapid or safe way existed to validate air transport models with realistic particles in the range of 1-10 microns. Successful DNATrax testing was conducted at the Pentagon in November 2012 in conjunction with the Pentagon Force Protection Agency. This study enhanced the team's understanding of indoor ventilation environments created by heating, ventilation and air conditioning (HVAC) systems. Among the applications for the new material are indoor air quality detection, for homes, offices, ships and airplanes; urban particulate tracking for subway stations, train stations and convention centers and environmental release tracking. Among the Livermore scientists who developed DNATrax are: team leader George Farquar, Elizabeth Wheeler, Ruth Udey, Beth Vitalis, Roald Leif, Brian Baker, Christine Hara, Cindy Thomas, Maxim Shusteff and Sally Hall.

Earth System Grid Federation (ESGF) | 2013

LLNL and 11 partner institutions developed the Earth System Grid Federation (ESGF) to serve the data-driven needs of the climate research community. The collaboration was honored as an "outstanding partnership." The ESGF supports the Coupled Model Intercomparison Project (CMIP), which was established in 1995 by the World Climate Research Programme's Working Group on Coupled Modeling to provide a community-based infrastructure for global climate model diagnosis, validation, intercomparison and data access. CMIP simulation model runs are key components of the periodic assessments of the Intergovernmental Panel on Climate Change (IPCC). The IPCC - and the scientists whose research supported the IPCC, including those from the ESGF - shared the 2007 Nobel Peace Prize. To date, ESGF has made available more than 60 large-scale CMIP5 simulation model runs (more than 1.8 petabytes of data) from 27 worldwide climate research centers spanning 21 countries. In addition to LLNL, which leads the ESGF effort, partners in the federation include Oak Ridge, Argonne and Lawrence Berkeley national laboratories, NASA's Jet Propulsion Laboratory, the Pacific Marine Environmental Laboratory, the German Climate Computing Center, the Euro-Mediterranean Center on Climate Change, the British Atmospheric Data Centre, Goddard Space Flight Center, the Geophysical Fluid Dynamics Laboratory and the Institut Pierre Simon Laplace.

Rapid Viability Polymerase Chain Reaction (RV-PCR) | 2013

Scientists from LLNL and the U.S. Environmental Protection Agency (EPA) have partnered to develop he Rapid Viability Polymerase Chain Reaction (RV-PCR), a method for detecting viable anthrax-causing spores. Their collaboration netted the team an "outstanding partnership" award. The need for processing large numbers of samples - and doing it speedily - was demonstrated during the 2001 congressional building anthrax contamination when more than 10,000 environmental samples were analyzed, and the facility reopening was significantly delayed pending sample results. Current testing methods require more labor and time, so that only about 30 samples may be processed per day, with confirmed results in about two days. The RV-PCR technology permits more than 150 samples to be processed in 48 hours for confirmed results, with some data as early as 15 hours. Efforts are now under way to transition the technology to Environmental Laboratory Response Network laboratories in the event of a possible future anthrax attack. Members of the RV-PCR team included: Staci Kane, Sonia Letant, Gloria Murphy and Teneile Alfaro of LLNL and Sanjiv Shah of the EPA.

Outstanding Commercialization Success - Integrated Dynamic Electron Solutions | 2012

An instrument -- called the dynamic transmission electron microscope, or DTEM - that has been developed by LLNL scientists provides never-before-seen details of material processes in 15-nanosecond (billionth of a second) single-shot exposures. The DTEM technology, which has been licensed to a Belmont, Calif.-based company, Integrated Dynamic Electron Solutions (IDES). After working with LLNL scientists to develop a prototype machine, the firm sold and installed a DTEM at Ecole Polytechnique Federale de Lausanne in Switzerland last year and is now developing concepts for new instruments based on other LLNL technologies.

Outstanding Partnership - i-GATE Innovation Hub | 2012

i-GATE (the Innovation for Green Advanced Transportation Excellence)creates a link between national laboratories and entrepreneurs, industry, innovation network, venture capital and universities to accelerate the commercialization of innovative energy technologies. After its first year of operation, the i-GATE incubator has assisted in the creation of 62 direct and 118 indirect jobs. Clients range from fuel cell and battery companies to ultra-light commuter rail and solid-state energy harvesters.

Outstanding Partnership - IntelliProbe Optical Breast Cancer Diagnostic System | 2012

A new medical technology, dubbed the "Intelliprobe" has been developed by scientists from the Russian Federal Nuclear Center; BioTelligent, Inc., a Livermore-based company; and LLNL. The "Intelliprobe" system may eliminate or substantially reduce the need for biopsies, tissue sample analysis by doctors, and the time for patients to obtain their medical results.

Outstanding Commercialization Success - Commercialization of Glycophorin Cell Lines with eBioscience, Inc. | 2011

Ida Shum is the IPO Business Development Executive for the project. The company provides innovative high quality reagents to researchers worldwide that empower the process of scientific discovery in the area of cellular immunity and oncology. eBioscience has an extensive portfolio of leading edge cell analysis products and technologies.

Outstanding Technology Development - MEMS-Based Adaptive Optics Optical Coherence Tomography | 2011

Developers of the technology include Scot Olivier, Diana Chen, and Steve Jones. Genaro Mempin is the Business Development Executive for the technology. The MEMs-Based Adaptive Optics Optical Coherence Tomography is a clinical instrument that provides noninvasive, ultra-high resolution, 3-D volumetric retinal images for eye doctors to view retinal structures at the cellular level. Prototypes are located at UC Davis and Indiana University.

Technology Transfer Professional of the Year - Catherine Elizondo "Motherhood and Apple Pie Recipes for Technology Transfer" | 2011

Catherine was selected for this new award due to her proven success in transferring LLNL-developed technologies that have led to product commercialization.

Outstanding Partnership – Environmental Sample Processor (ESP) | 2010

The ESP allows for use of DNA and protein array techniques and quantitative polymerase chain reaction (PCR) techniques to sense microbial community structure and detect specific genes and gene products remotely within an ocean observing network. Members of the ESP team include LLNL's John Dzenitis and Vincent Riots, Chris Scholin of Monterey Bay Aquarium Research Institute (MBARI), and Chris Melancon of Spyglass Biosecurity Inc.Spyglass was awarded licenses from MBARI and LLNL for ESP. Catherine Elizondo is the IPO Business Development Executive for the project.

Outstanding Partnership – GeMini | 2010

GeMini is a portable gamma-ray spectrometer based on germanium technology. Small enough to fit in the palm of a hand, this spectrometer is equipped with an innovative low-powered, miniature cooling mechanism. GeMini was launched on NASA's Mercury MESSENGER spacecraft and is now taking the first-ever gamma-ray data of the planet Mercury. GeMini also can be used to help prevent the smuggling of nuclear materials and can assist in the implementation of international safeguards for nuclear fuel cycles. This work was supported by the Defense Threat Reduction Agency and the National Nuclear Security Administration's Office of Dismantlement and Transparency to advance the Next Generation Safeguards Initiative. Nucsafe Inc., has licensed the GeMini technology developed by a team of LLNL scientists and engineers led by Morgan Burks. Catherine Elizondo has been IPO's business development executive for this project.

Outstanding Commercialization Success - Commercialization of Glycophorin Cell Lines with eBioscience, Inc. | 2009

Ida Shum is the IPO Business Development Executive for the project. The company provides innovative high quality reagents to researchers worldwide that empower the process of scientific discovery in the area of cellular immunity and oncology. eBioscience has an extensive portfolio of leading edge cell analysis products and technologies.

Outstanding Technology Development - MEMS-Based Adaptive Optics Optical Coherence Tomography | 2009

Developers of the technology include Scot Olivier, Diana Chen, and Steve Jones. Genaro Mempin is the Business Development Executive for the technology. The MEMs-Based Adaptive Optics Optical Coherence Tomography is a clinical instrument that provides noninvasive, ultra-high resolution, 3-D volumetric retinal images for eye doctors to view retinal structures at the cellular level. Prototypes are located at UC Davis and Indiana University.

Technology Transfer Professional of the Year - Catherine Elizondo "Motherhood and Apple Pie Recipes for Technology Transfer" | 2009

Catherine was selected for this new award due to her proven success in transferring LLNL-developed technologies that have led to product commercialization.

Outstanding Commercialization Success - Durable Silver Reflector for High Efficiency Solar Cells | 2008

Jesse Wolfe, Randall D. Elder, Dave Sanders and Ted Saito.

Outstanding Commercialization Success – Fission Meter: A High-Sensitivity, Advanced Portable Neutron Source Identification System | 2008

Mark Rowland, Catherine Elizondo, Dan Dietrich and Raymond Pierce

Outstanding Technology Development – Dielectric Wall Accelerator for Proton Therapy | 2008

George Caporaso, Steve Sampayan and Genaro Mempin.