This invention solves a limitation in the current practice of adding hydroxyl functional groups to the aminopolymer through the use of an alternative synthetic approach. The novelty of our approach is to produce new structurally modified relatives of common aminopolymers (PEI and PPI) as well as new functionalized materials in which the hydroxyl groups are tethered to a carbon in the backbone…

This invention describes a multiple nozzle microfluidic unit that allows simultaneous generation streams of multiple layered coaxial liquid jets. Liquids are pumped into the device at a combined flow rate from 100 mL/hr to 10 L/hr. Droplets are created with diameters in the range of 1 µm to 5 mm and can be created with 1-2 shell layers encapsulating fluid. Droplets created from the system can…

LLNL’s high throughput method involves proteome-wide screening for linear B-cell epitopes using native proteomes isolated from a pathogen of interest and convalescent sera from immunized animals. LLNL researchers have applied their newly developed generalizable screening method to the identification of pathogenic bacteria by screening linear B-cell epitopes in the proteome of Francisella…

There are prominent technical challenges arising from spinning a battery on the order of kilohertz as required by magic angle spinning in order to obtain spectral resolution that are addressed and enable operando solid-state NMR. The operando NMR measurement allows for continuous monitoring of the battery components and of potential metastable states that may exist during…

LLNL has a patented process to produce colloidal silica directly from geothermal fluids. Livermore’s process uses membranes to produce a mono-dispense slurry of colloidal silica particles for which there are several applications. LLNL has demonstrated that colloidal silica solutions that result from extraction of silica from geothermal fluids undergo a transition to a solid gel over a range of…

LLNL has developed a novel process of production, isolation, characterization, and functional re-constitution of membrane-associated proteins in a single step. In addition, LLNL has developed a colorimetric assay that indicates production, correct folding, and incorporation of bR into soluble nanolipoprotein particles (NLPs).

LLNL has developed an approach, for formation of NLP/…