LLNL’s high throughput method involves proteome-wide screening for linear B-cell epitopes using native proteomes isolated from a pathogen of interest and convalescent sera from immunized animals. LLNL researchers have applied their newly developed generalizable screening method to the identification of pathogenic bacteria by screening linear B-cell epitopes in the proteome of Francisella…

LLNL has developed a novel process of production, isolation, characterization, and functional re-constitution of membrane-associated proteins in a single step. In addition, LLNL has developed a colorimetric assay that indicates production, correct folding, and incorporation of bR into soluble nanolipoprotein particles (NLPs).

LLNL has developed an approach, for formation of NLP/…

The SLIDER deflector includes a waveguide, a serrated mask positioned above the waveguide cladding, and a synchronized pump beam. The pump beam illuminates the serrated mask with a short pulse and transfers its pattern to the guiding layer where it imprints a sequence of prisms. The prisms are activated via nonlinear optical effects in the semiconductor and persist for the duration of the…