LLNL’s high throughput method involves proteome-wide screening for linear B-cell epitopes using native proteomes isolated from a pathogen of interest and convalescent sera from immunized animals. LLNL researchers have applied their newly developed generalizable screening method to the identification of pathogenic bacteria by screening linear B-cell epitopes in the proteome of Francisella…
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![Immunoproteomic workflow to identify antigenic peptides.](/sites/default/files/styles/scale_exact_400x400_/public/2023-04/Immunoproteomic_workflow.png?itok=unIjnCCK)
![LLNL has developed a new method for increasing lifetime in quantum coherent devices.](/sites/default/files/styles/scale_exact_400x400_/public/2020-09/Quantum%20Coherent%20Devices.gif?itok=kv1ZYIim)
LLNL has developed a method of extending device lifetimes by imprinting into the device a shape that excludes specific vibrational modes, otherwise known as a phononic bandgap. Eliminating these modes prevents one of the primary energy loss pathways in these devices. LLNL’s new method enhances the coherence of superconducting circuits by introducing a phononic bandgap around the system’s…
![Sequoia computer panels off](/sites/default/files/styles/scale_exact_400x400_/public/2022-06/Sequoia%20HPC.jpg?itok=sHb2NE1F)
LLNL has developed a new active memory data reorganization engine. In the simplest case, data can be reorganized within the memory system to present a new view of the data. The new view may be a subset or a rearrangement of the original data. As an example, an array of structures might be more efficiently accessed by a CPU as a structure of arrays. Active memory can assemble an alternative…
![nanolipoprotein particles](/sites/default/files/styles/scale_exact_400x400_/public/2022-06/nanolipoprotein%20particles.jpg?itok=nQgwpZE3)
LLNL has developed a novel process of production, isolation, characterization, and functional re-constitution of membrane-associated proteins in a single step. In addition, LLNL has developed a colorimetric assay that indicates production, correct folding, and incorporation of bR into soluble nanolipoprotein particles (NLPs).
LLNL has developed an approach, for formation of NLP/…