LLNL researchers have developed a TDLAS-based, standalone, real-time gas analyzer in a small form-factor for continuous or single-point monitoring. The system can analyze multiple gases with ultra-high sensitivity (ppm detection levels) in harsh conditions when utilizing wavelength-modulation spectroscopy (WMS).
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![OALV design with High-k Photoconductor and High-k Optical Window](/sites/default/files/styles/scale_exact_400x400_/public/2024-01/OALV%20design.png?itok=xMV74hXb)
LLNL researchers has developed designs to augment WBG/UWBG-based OALVs to improve their power handling capability under CW operational environments. These designs include:
![Schematic of 2P3C setup. Pump laser component is in red while probe laser component is denoted in blue.](/sites/default/files/styles/scale_exact_400x400_/public/2023-05/trace%20gas%20detection%20with%202P3C%20ring-down%20spectroscopy_0.jpg?itok=FcMiekn3)
LLNL’s novel approach combines 2-color spectroscopy with CRDS, a combination not previously utilized.
![Segments of transmission line lengths can be switched to open circuit (as shown) or shorted to the ground (not shown)](/sites/default/files/styles/scale_exact_400x400_/public/2023-05/Segments%20of%20tranmission%20line%20lengths.png?itok=FF0qaBGw)
Design and construction of a photoconductive switch requires a diamond photoconductor illuminated by light of a certain excitation wavelength. The diamond material is specifically doped with substitutional nitrogen, which act as a source of electrons. The device architecture allows maximum light entering the aperture. The top and bottom electrodes are made of ultra wide band gap (UWBG)…
![Annular illumination on photo conductor by Conical Total Internal Reflection “CTIR” endcap](/sites/default/files/styles/scale_exact_400x400_/public/2023-05/CONIFR.png?itok=L4wSanXF)
The approach is to use a custom-designed frustrum and attach it to the optical fiber that connects to the PCSS. Light from the fiber enters the frustrum, spreads out, and enters the PCSS. Any unabsorbed light re-enters the frustrum and, because of its geometry, reflects back into the PCSS itself with only a negligible fraction escaping from the fiber. The shape of the novel frustrum is…
![Immunoproteomic workflow to identify antigenic peptides.](/sites/default/files/styles/scale_exact_400x400_/public/2023-04/Immunoproteomic_workflow.png?itok=unIjnCCK)
LLNL’s high throughput method involves proteome-wide screening for linear B-cell epitopes using native proteomes isolated from a pathogen of interest and convalescent sera from immunized animals. LLNL researchers have applied their newly developed generalizable screening method to the identification of pathogenic bacteria by screening linear B-cell epitopes in the proteome of Francisella…
![OTV Image](/sites/default/files/styles/scale_exact_400x400_/public/2022-02/OTV%20Image.png?itok=KEAmHqpM)
The Optical Transconductance Varistor (OTV, formerly Opticondistor) overcomes depletion region voltage limitations by optically exciting wide bandgap materials in a compact package. A 100μm thick crystal could have the capability approaching 40kV and would replace numerous equivalent junction devices. Thus, unlike present junction transistors or diodes, this wide bandgap device can be stacked…
![nanolipoprotein particles](/sites/default/files/styles/scale_exact_400x400_/public/2022-06/nanolipoprotein%20particles.jpg?itok=nQgwpZE3)
LLNL has developed a novel process of production, isolation, characterization, and functional re-constitution of membrane-associated proteins in a single step. In addition, LLNL has developed a colorimetric assay that indicates production, correct folding, and incorporation of bR into soluble nanolipoprotein particles (NLPs).
LLNL has developed an approach, for formation of NLP/…