LLNL researchers have devised a set of design principles that facilitates the development of practical TPMS-based two fluid flow reactors.; included in the design are these new concepts:
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![Potential reactor configurations with printed TPMS scaffolds](/sites/default/files/styles/scale_exact_400x400_/public/2023-12/Reactor_Config_with_TPMS_scaffolds.png?itok=stDW7Z7n)
![Filled (8,8) (left) and (15,15) (right) CNTs with [EMIM+][BF4- ] using SGTI with the proposed spliced soft-core potential (SSCP) approach](/sites/default/files/styles/scale_exact_400x400_/public/2023-10/Filled%20CNTs%20using%20SGTI.png?itok=Dy0ObN7i)
LLNL researchers have developed a novel simulation methodology using slow growth thermodynamic integration (SGTI) utilizing spliced soft-core interaction potential (SSCP). The approach to filling the molecular enclosures is a nonphysical one. Rather than filling the pores from the open ends this method creates steps in the algorithm that allow molecules to pass through the pore wall and…
![Flexible optoelectronic chip with integrated transmitter and receiver subassemblies](/sites/default/files/styles/scale_exact_400x400_/public/2023-04/Flexible_optoelectronic_chip.png?itok=EVf8ujMo)
Commercial fiber optic cables are the current standard for carrying optical signals in industries like communications or medical devices. However, the fibers are made of glass, which do not have favorable characteristics for applications that require flexibility and re-routing, e.g. typically brittle, limited selection of materials, dimension constraints.
![Mycobacterium tuberculosis](/sites/default/files/styles/scale_exact_400x400_/public/2022-07/Tuberculosis.jpg?itok=Am8SJWPD)
LLNL researchers have developed a high-volume, low-cost diagnostic test that is easy to use and provides results in under an hour. The testing platform will provide emergency responders and other medical professionals with the ability to screen individuals using oral and nasal samples, and obtain results in approximately 30 minutes. This point-of-care testing approach will enable rapid triage…
![DNA](/sites/default/files/styles/scale_exact_400x400_/public/2022-07/DNA.jpg?itok=ES9MRz5G)
LNLL scientists have invented a method for multiplexed detection of PCR amplified products which can be completed in a single step. Highly validated species-specific primer sets are used to simultaneously amplify multiple diagnostic regions unique to each individual pathogen. Resolution of the mix of amplified products is achieved by PCR product hybridization to corresponding probe sequences,…
![blue bacteria](/sites/default/files/styles/scale_exact_400x400_/public/2022-07/blue%20bacteria.jpg?itok=ddcclBXg)
This LLNL-developed invention is multiplexed and utilizes the Luminex bead-based liquid array, which contains 100 different unique beads. Oligonucleotide probes with sequences complementary to the target sequences are covalently coupled to these unique beads. These capture beads are mixed with viral samples obtained from the patient via cheek swabbing or a throat wash and subjected to PCR in a…
![Cow](/sites/default/files/styles/scale_exact_400x400_/public/2022-07/Cow.jpg?itok=ZMhJc1KF)
LLNL scientists have developed a high-confidence, real-time multiplexed reverse transcriptase PCR (RT-PCR) rule-out assay for foot and mouth disease virus (FMDV). It utilizes RT-PCR to amplify both DNA and RNA viruses in a single assay to detect FMDV as well as rule out other viruses that cause symptoms in livestock indistinguishable from those caused by FMDV, such as Bovine Herpes Virus-1 (…
![biosecurity petri dish](/sites/default/files/styles/scale_exact_400x400_/public/2022-07/biosecurity%20petri%20dish.jpg?itok=nHRadA1E)
LLNL researchers have invented a system for identifying all known and unknown pathogenic or non-pathogenic organisms in a sample. This invention takes a complex sample and generates droplets from it. The droplets consist of sub-nanoliter volume reactors which contain the organism sized particles. A lysis device lyses the organisms and releases the nucleic acids. An amplifier then magnifies the…
![passive flow lateral device](/sites/default/files/styles/scale_exact_400x400_/public/2022-07/passive%20flow%20lateral%20device.jpg?itok=_ChAMmkc)
LLNL researchers have developed a portable device which analyzes one or multiple types of body fluids or gases to test for one or more medical conditions. A bodily fluid (such as blood, perspiration, saliva, breath, or urine) is put into a condenser surface and is then separated into both a primarily gas fluid component and a second one that is primarily liquid. These two samples from the same…
![Corona virus](/sites/default/files/styles/scale_exact_400x400_/public/2022-07/coronavirus.jpg?itok=CAaxyotI)
LLNL researchers have developed a method to quickly and accurately identify the family of a virus infecting a vertebrate via PCR. Universal primer sets consisting of short nucleic acid strands of 7 to 30 base pairs in length were created to amplify target sequences of viral DNA or RNA. These primers can amplify certain identifying sequences of all viral genomes sequenced to date as well as…
![image_of_the_device.png image_of_the_device](/sites/default/files/styles/scale_exact_400x400_/public/2019-08/image_of_the_device.png?itok=RQ0-VBQm)
LLNL scientists have developed a battery-powered device which is low-cost and multi-chambered for the extraction and amplification of nucleic acids from environmental, clinical, and laboratory samples via loop-mediated isothermal amplification (LAMP). This platform identifies pathogenic bacteria and assists in determining the optimal treatment plan. A multi-chamber amplification cartridge in…
![Retina](/sites/default/files/styles/scale_exact_400x400_/public/2022-07/retina.jpg?itok=PMxD0RVZ)
LLNL scientists have developed a method to ensure the accuracy of that tomographic image by applying adaptive optics (AO) to OCT in a single instrument (AO-OCT). AO stabilizes the image being captured by the OCT device by utilizing a Hartmann-Shack wavefront sensor and a deformable mirror, a type of mirror designed to compensate for detected waveform abnormalities (such as ones caused by a…
![Autonomous detection, Bio watch, airborne detection](/sites/default/files/styles/scale_exact_400x400_/public/2022-07/autonomous%20detection.jpg?itok=4hu1aQYK)
LLNL scientists have created a standalone pathogen identifier that can be placed in public settings, such as in stores or on street corners. Not unlike an ATM in physical size, this kiosk will accept biological samples from an individual for multiplexed analysis. The sample collection process will be sufficiently simple such that anyone could begin the diagnostic process after making the…
![Nanoporus gold](/sites/default/files/styles/scale_exact_400x400_/public/2022-06/nanoporus%20gold%20875x500.jpg?itok=A0gFmVPT)
By combining 3D printing and dealloying., researchers at LLNL have developed a method for fabricating metal foams with engineered hierarchical architectures consisting of pores at least 3 distinct length scales. LLNL’s method uses direct ink writing (DIW), a 3D printing technique for additive manufacturing to fabricate hierarchical nanoporous metal foams with deterministically controlled 3D…
![drift_meter_thumb.jpg drift_meter_thumb](/sites/default/files/styles/scale_exact_400x400_/public/2019-08/drift_meter_thumb.jpg?itok=1NiNsyHm)
LLNL’s Optically-based Interstory Drift Meter System provides a means to accurately measure the dynamic interstory drift of a vibrating building (or other structure) during earthquake shaking. This technology addresses many of the shortcomings associated with traditional strong motion accelerometer based building monitoring.
LLNL’s discrete diode position sensitive device is a newly…
![Retina](/sites/default/files/styles/scale_exact_400x400_/public/2022-07/retina.jpg?itok=PMxD0RVZ)
Using various excitation wavelengths, a hyperspectral microscope takes advantage of autofluorescence and polarized light scattering from cellular components to obtain composite images that highlight their presence. The light collection efficiency is maximized to achieve image acquisition times and rates suitable for in vivo applications.
![intracranial hematoma detector](/sites/default/files/styles/scale_exact_400x400_/public/2022-07/intracranial%20hematoma%20detector.jpg?itok=-jBgXVpX)
The patented intracranial hematoma detection technology uses Micropower Impulse Radar (MIR). MIR uses short, high frequency electromagnetic pulses to obtain information in a non-invasive manner. Unlike ultrasound and other electromagnetic techniques, MIR can operate well through the skull, which is of great importance for intracerebral as well as epidural and subdural hematomas. The MIR…
![energy_absorbing_material.jpg energy_absorbing_material](/sites/default/files/styles/scale_exact_400x400_/public/2019-08/energy_absorbing_material.jpg?itok=UxNZ6nWH)
To overcome limitations with cellular silicone foams, LLNL innovators have developed a new 3D energy absorbing material with tailored/engineered bulk-scale properties. The energy absorbing material has 3D patterned architectures specially designed for specific energy absorbing properties. The combination of LLNL's capabilities in advanced modeling and simulation and the additive…
![Electronic Wave](/sites/default/files/styles/scale_exact_400x400_/public/2022-06/electronic%20wave.jpg?itok=v7aKMJKH)
The invention relates to a measurement method and system for capturing both the amplitude and phase temporal profile of a transient waveform or a selected number of consecutive waveforms having bandwidths of up to about 10 THz in a single shot or in a high repetition rate mode. The invention consists of an optical preprocessor which can then output a time-scaled replica of the input signal to…