This invention proposes using a pulse laser configured to generate laser pulses and a controller for controlling operation of the pulse laser. The controller is further configured to control the pulse laser to cause the pulse laser to generate at least one of the laser pulses with a spatiotemporally varying laser fluence over a duration of at least one of the laser pulses. The spatiotemporally…

To address shortcomings of current liposome drug delivery systems, the patented innovation uses drug-loaded liposomes containing carbon nanotube porins (CNTPs) inserted into the liposomal membranes for the delivery of the encapsulated drugs. Short CNTPs (10 nm in length) with narrow diameter (0.8 nm) has been demonstrated to facilitate efficient fusion of lipid bilayers resulting in the…

A new approach of developing synthetic antibacterial mineral assemblages can be used as an alternative treatment when traditional antibiotics fail in clinical and agricultural settings. Mineral mixtures can be synthesized with tunable metal release and reactive oxygen species generation that are capable of killing human pathogens and promoting wound healing. One of the key components in the…

The method described in a pending patent application uses a novel thiacrown (dibenzohexathia-18-crown-6) for efficient extraction of ^197m,gHg and ^197gHg from irradiated Pt target foils. The separation of ^197m,gHg and ^197gHg from Pt foils using this novel thiacrown was found to be highly specific. No detectable amount of the Pt foil was seen in the…

Combining the principles of nanotechnology, cell-free protein synthesis and microfluidics, LLNL researchers have developed a reusable, portable programmable system that can create purified, concentrated protein product in vitro in a microfluidic device containing nucleic acids.

Lawrence Livermore National Laboratory (LLNL) is offering the opportunity to collaborate in accelerating artificial intelligence (AI) for applied science, including research in key areas such as advanced material design, 3D printing, predictive biology, energy systems, “self-driving” lasers and fusion energy research.

Clinical images have a wealth of data that are currently untapped by physicians and machine learning (ML) methods alike. Most ML methods require more data than is available to sufficiently train them. In order to obtain all data contained in a clinical image, it is imperative to be able to utilize multimodal, or various types of, data such as tags or identifications, especially where spatial…

Some COVID-19 diagnoses are utilizing computed tomography (CT)-scans for triage. CT-scans produce immediate results with high sensitivity. The digital images produced by a CT-scan require physicians to identify objects within the image to determine the presence of disease. Object identification can be done using machine learning (ML) techniques such as deep learning (DL) to improve speed and…

MimicGAN represents a new generation of methods that can “self-correct” for unseen corruptions in the data out in the field. This is particularly useful for systems that need to be deployed autonomously without needing constant intervention such as Automated Driver Assistance Systems. MimicGAN achieves this by treating every test sample as “corrupt” by default. The goal is to determine (a) the…

LLNL scientists developed novel hydrogels, which are biodegradable soft materials synthesized by a water-soluble polymer. Incorporating silver imparts antimicrobial activity to the material at low concentration compared to currently used silver nanoparticles. Our hydrogels are composed of silver ions instead of silver nanoparticles, which eliminates the toxicity concerns of modern silver…

LLNL has developed a new system, called the Segmentation Ensembles System, that provides a simple and general way to fuse high-level and low-level information and leads to a substantial increase in overall performance of digital image analysis. LLNL researchers have demonstrated the effectiveness of the approach on applications ranging from automatic threat detection for airport security, to…

The new LLNL technique works by transiently removing and trapping concrete or rock surface material, so that contaminants are confined in a manner that is easy to isolate and remove. Our studies suggest that 10 m² of surface could be processed per hour. The technique easily scales to more surface/hr.

LLNL’s system consists of one or more flashlamp-pumped Nd:glass zig-zag amplifiers, a very low threshold stimulated-Brillouin-scattering (SBS) phase conjugator system, and a free-running single frequency Nd:YLF master oscillator.