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CT Scanner Adobe Stock Image

The essence of this invention is a method that couples network architecture using neural implicit representations coupled with a novel parametric motion field to perform limited angle 4D-CT reconstruction of deforming scenes.

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MonoTel Compact Monolithic Space Telescope

Rapid monolith development at scale is achieved through use of a functionally equivalent optic simulant made from a low-cost material to substitute the functional optic. Monolith optical performance is affected not only by thermal expansion but also by temperature inhomogeneity due to the temperature dependence of refractive index.

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MonoTel Compact Monolithic Space Telescope

Aeroptics are a proposed new class of monolithic optical system in aerogel fabricated by molding around a master mandrel. This approach combines the intrinsic stability of proven monolithic telescopes, with the ultralow density of silica aerogels. In Aeroptics, the monolith is hollow with an aerogel substrate providing a supporting structure. Theoretically, Aeroptics could enable 1-m aperture…

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MonoTel Compact Monolithic Space Telescope

This invention achieves both a wider field of view and faster f-number within a monolithic substrate by incorporating an aspheric convex refractive first surface and a planar aspheric field corrector surface on the final refractive surface. These two refractive surfaces work in conjunction with a concave aspheric primary and convex aspheric secondary mirror (e.g. Cassegrain type) to improve…

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Flexible optoelectronic chip with integrated transmitter and receiver subassemblies

Commercial fiber optic cables are the current standard for carrying optical signals in industries like communications or medical devices. However, the fibers are made of glass, which do not have favorable characteristics for applications that require flexibility and re-routing, e.g. typically brittle, limited selection of materials, dimension constraints.

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Livermore Tomography Tools  LTT

To solve these challenges using new and existing CT system designs, LLNL has developed an innovative software package for CT data processing and reconstruction. Livermore Tomography Tools (LTT) is a modern integrated software package that includes all aspects of CT modeling, simulation, reconstruction, and analysis algorithms based on the latest research in the field. LTT contains the most…

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Mycobacterium tuberculosis

LLNL researchers have developed a high-volume, low-cost diagnostic test that is easy to use and provides results in under an hour. The testing platform will provide emergency responders and other medical professionals with the ability to screen individuals using oral and nasal samples, and obtain results in approximately 30 minutes. This point-of-care testing approach will enable rapid triage…

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blue bacteria

This LLNL-developed invention is multiplexed and utilizes the Luminex bead-based liquid array, which contains 100 different unique beads. Oligonucleotide probes with sequences complementary to the target sequences are covalently coupled to these unique beads. These capture beads are mixed with viral samples obtained from the patient via cheek swabbing or a throat wash and subjected to PCR in a…

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Cow

LLNL scientists have developed a high-confidence, real-time multiplexed reverse transcriptase PCR (RT-PCR) rule-out assay for foot and mouth disease virus (FMDV). It utilizes RT-PCR to amplify both DNA and RNA viruses in a single assay to detect FMDV as well as rule out other viruses that cause symptoms in livestock indistinguishable from those caused by FMDV, such as Bovine Herpes Virus-1 (…

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biosecurity petri dish

LLNL researchers have invented a system for identifying all known and unknown pathogenic or non-pathogenic organisms in a sample. This invention takes a complex sample and generates droplets from it. The droplets consist of sub-nanoliter volume reactors which contain the organism sized particles. A lysis device lyses the organisms and releases the nucleic acids. An amplifier then magnifies the…

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Corona virus

LLNL researchers have developed a method to quickly and accurately identify the family of a virus infecting a vertebrate via PCR. Universal primer sets consisting of short nucleic acid strands of 7 to 30 base pairs in length were created to amplify target sequences of viral DNA or RNA. These primers can amplify certain identifying sequences of all viral genomes sequenced to date as well as…

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passive flow lateral device

LLNL researchers have developed a portable device which analyzes one or multiple types of body fluids or gases to test for one or more medical conditions. A bodily fluid (such as blood, perspiration, saliva, breath, or urine) is put into a condenser surface and is then separated into both a primarily gas fluid component and a second one that is primarily liquid. These two samples from the same…

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Retina

LLNL scientists have developed a method to ensure the accuracy of that tomographic image by applying adaptive optics (AO) to OCT in a single instrument (AO-OCT). AO stabilizes the image being captured by the OCT device by utilizing a Hartmann-Shack wavefront sensor and a deformable mirror, a type of mirror designed to compensate for detected waveform abnormalities (such as ones caused by a…

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image_of_the_device

LLNL scientists have developed a battery-powered device which is low-cost and multi-chambered for the extraction and amplification of nucleic acids from environmental, clinical, and laboratory samples via loop-mediated isothermal amplification (LAMP). This platform identifies pathogenic bacteria and assists in determining the optimal treatment plan. A multi-chamber amplification cartridge in…

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DNA

LNLL scientists have invented a method for multiplexed detection of PCR amplified products which can be completed in a single step. Highly validated species-specific primer sets are used to simultaneously amplify multiple diagnostic regions unique to each individual pathogen. Resolution of the mix of amplified products is achieved by PCR product hybridization to corresponding probe sequences,…

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Autonomous detection, Bio watch, airborne detection

LLNL scientists have created a standalone pathogen identifier that can be placed in public settings, such as in stores or on street corners. Not unlike an ATM in physical size, this kiosk will accept biological samples from an individual for multiplexed analysis. The sample collection process will be sufficiently simple such that anyone could begin the diagnostic process after making the…

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monolithic_telescope

Monolithic Telescopes are a novel implementation of a solid catadioptric design form, instantiated in a monolithic block of fused silica.

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Retina

Using various excitation wavelengths, a hyperspectral microscope takes advantage of autofluorescence and polarized light scattering from cellular components to obtain composite images that highlight their presence. The light collection efficiency is maximized to achieve image acquisition times and rates suitable for in vivo applications.

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Space-based Telescopes for Actionable Refinement of Ephemeris (STARE)

LLNL is developing the Space-based Telescopes for Actionable Refinement of Ephemeris (STARE). STARE is a constellation of low cost nano-satellites (less than 5Kg) in low-earth orbit dedicated to the observation of space debris in conjunction with a ground-based infrastructure for maintenance, coordination and data processing. Each nano-satellite in the constellation is capable of recording an…