LLNL researchers have designed and developed a novel high-density, high-channel count 3D connector that enables hundreds or thousands of nonpermanent connections within a compact footprint. The connector addresses limitations of currently used conventional approaches that were described previously, which have an artificial ceiling on the number of recording sites of modern devices of no more…
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![Schematic of high density detachable electrical interfaces with a single layer](/sites/default/files/styles/scale_exact_400x400_/public/2023-04/High%20density%20detachable%20interface_single.png?itok=HqwlqXwl)
Many of the disadvantages of current interface devices can be overcome with LLNL’s novel interface design, which relies on area array distribution where independent interface connector subassemblies are positioned in a planar grid. Not only is the interface device expandable area-wise (without increasing contact force), but it could also be expanded height-wise, with multiple layers of these…
![Immunoproteomic workflow to identify antigenic peptides.](/sites/default/files/styles/scale_exact_400x400_/public/2023-04/Immunoproteomic_workflow.png?itok=unIjnCCK)
LLNL’s high throughput method involves proteome-wide screening for linear B-cell epitopes using native proteomes isolated from a pathogen of interest and convalescent sera from immunized animals. LLNL researchers have applied their newly developed generalizable screening method to the identification of pathogenic bacteria by screening linear B-cell epitopes in the proteome of Francisella…
![Flexible optoelectronic chip with integrated transmitter and receiver subassemblies](/sites/default/files/styles/scale_exact_400x400_/public/2023-04/Flexible_optoelectronic_chip.png?itok=EVf8ujMo)
Commercial fiber optic cables are the current standard for carrying optical signals in industries like communications or medical devices. However, the fibers are made of glass, which do not have favorable characteristics for applications that require flexibility and re-routing, e.g. typically brittle, limited selection of materials, dimension constraints.
![LLNL has developed a new method for increasing lifetime in quantum coherent devices.](/sites/default/files/styles/scale_exact_400x400_/public/2020-09/Quantum%20Coherent%20Devices.gif?itok=kv1ZYIim)
LLNL has developed a method of extending device lifetimes by imprinting into the device a shape that excludes specific vibrational modes, otherwise known as a phononic bandgap. Eliminating these modes prevents one of the primary energy loss pathways in these devices. LLNL’s new method enhances the coherence of superconducting circuits by introducing a phononic bandgap around the system’s…
![iChip, brain on a chip](/sites/default/files/styles/scale_exact_400x400_/public/2022-07/iChip.jpg?itok=B-rQJQjn)
LLNL has developed a brain-on-a-chip system with a removable cell-seeding funnel to simultaneously localize neurons from various brain regions in an anatomically relevant manner and over specific electrode regions of a MEA. LLNL’s novel, removable cell seeding funnel uses a combination of 3D printing and microfabrication that allows neurons from select brain regions to easily be seeded into…
![nanolipoprotein particles](/sites/default/files/styles/scale_exact_400x400_/public/2022-06/nanolipoprotein%20particles.jpg?itok=nQgwpZE3)
LLNL has developed a novel process of production, isolation, characterization, and functional re-constitution of membrane-associated proteins in a single step. In addition, LLNL has developed a colorimetric assay that indicates production, correct folding, and incorporation of bR into soluble nanolipoprotein particles (NLPs).
LLNL has developed an approach, for formation of NLP/…