To address these challenges and explore the scale-up science of MXene, LLNL researchers have developed a scalable solution-phase synthesis method to generate MXene with over 70% production yield via top-down exfoliation approaches with non-aqueous solvents and salts. The novel method is a dramatic improvement compared to conventional approaches (10-20%). Furthermore, the shielding…
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LLNL researchers have developed a novel photocurable silicone useful for producing three-dimensional objects via additive manufacturing. The resin formulations consist of a mult-component siloxane polymers with different functionalities, a platinum catalyst, a photoinitiator, and other organic peroxides. The LLNL invention involves controlling the spatial and temporal aspects of the…
LLNL has developed a novel Production of Readily compressible dies for Enhanced Sintering of Solids (PRESS) method for ceramic parts manufacturing that uses compressible, non-sintering powder materials as a mold which can match the compaction of the ceramic powder starting materials during pressure-assisted sintering. PRESS enables uniform deformation of the part under a constant linear travel…
As an important step toward overcoming the technical and environmental limitations of current REE processing methods, the LLNL team has patented and demonstrated a biobased, all-aqueous REE extraction and separation scheme using the REE-selective lanmodulin protein. Lanmodulin can be fixed onto porous support materials using thiol-maleimide chemistry, which can enable tandem REE purification…
The essence of this invention is a method that couples network architecture using neural implicit representations coupled with a novel parametric motion field to perform limited angle 4D-CT reconstruction of deforming scenes.
LLNL researchers have developed an innovative and uniform single-pot polymer multi-material system, based on a combination of 3 different reactive chemistries. By combining the three different constituent monomers, fine control of mechanical attributes, such as elastic modulus, can be achieved by adjusting the dosage of UV light throughout the additive manufacturing process. This…
LLNL researchers have developed a method to incorporate gas phase synthesized graphene (GSG) as a unique additive in a UV-crosslinkable polymer formulation. The GSG is added by using a planetary mixer to obtain a homogenous suspension of GSG in polymer. The resulting formulation is highly stable and doesn't show signs of phase separation or solid sedimentation. The polymer formulation is then…
LLNL researchers developed a novel method to nucleate the alpha phase of Tantalum on a polymer surface at room temperature, allowing for the controllable formation of a variety of 3D structures, such as airbridges. Using this method with a subsequent Piranha etch results in the complete removal of the residues of the polymer 'scaffolding' or template while allowing the deposited tantalum…
LLNL researchers have developed a Li-Sn-Zn ternary alloy and its method of production. Instead of traditional alloying techniques, the alloy was synthesized using mechanical alloying (high energy ball milling). With high purity elemental powders of lithium, tin and zinc, LLNL researchers were able to prepare Li60Sn20Zn20 as well as Li70Sn20Zn10 nanopowders.
LLNL inventors have created innovative steps in the synthesis, carbonation and activation steps of aerogel manufacturing that allows for large scale production. These steps are:
1. Synthesis: a novel pre-cure step with subsequent gelation (RF precursor solution is heated with stirring to achieve a mixed liquid intermediate temperature, the precursor solution is then allowed to cool,…
CMI—a DOE Energy Innovation Hub—is a public/private partnership led by the Ames Laboratory that brings together the best and brightest research minds from universities, national laboratories (including LLNL), and the private sector to find innovative technology solutions to make better use of materials critical to the success of clean energy technologies as well as develop resilient and secure…
To overcome challenges that existing techniques for creating 3DGs face, LLNL researchers have developed a method that uses a light-based 3D printing process to rapidly create 3DG lattices of essentially any desired structure with graphene strut microstructure having pore sizes on the order of 10 nm. This flexible technique enables printing 3D micro-architected graphene objects with complex,…
The novel technology developed at LLNL is a new, effective means of separating and concentrating Sc from lanthanides and non-REEs in unconventional, waste-derived feedstocks, thereby transforming an essentially valueless solution into valuable Sc concentrates. The results represent an important advance in the development of an environmentally sustainable alternative to organic solvent-…
LLNL researchers along with collaborators at Pennsylvania State University have found that a newly discovered natural protein named Lanmodulin (LanM) could be a potential candidate for extracting REEs from ore or other sources such as coal ash as well as purifying the REE material. Through joint research, the scientists found that LanM undergoes a large conformational change in response…
LLNL researchers have developed a custom formulated extreme low viscosity reactive silicone resin base modified with a temperature dependent thixotrope along with a modified catalyst package. The uncatalyzed composition is capable of accepting loadings of polymer microspheres sufficient to produce a cured bulk rubber that has a density as low as 0.3 g/cc, thus compatible with high-…
Solid-state distributed node-based rapid thermal cycler for extremely fast nucleic acid amplification (LLNL Internal Case # IL-12275, US Patent 8,720,209)
Laser heating of aqueous samples on a micro-optical-electro-mechanical system (LLNL Internal Case # IL-11719, US Patents 8,367,976;
LLNL researchers have designed a synthetic, concatemeric bacterial expression vector that expresses a protein sequence that can be digested into a single peptide. The synthetic protein is designed to be secreted outside E. coli cells, and therefore can be purified using a His-tag from the cell supernatant (thereby reducing the need to lyse the cells for purification).
LLNL scientists have created a technology that utilizes electrical means, instead of optical methods, to (1) provide label-free detection of droplet morphology; (2) manipulate droplet position through trapping and actuation; (3) track individual droplets in a heterogeneous droplet population; and (4) generate droplets with target characteristics automatically without optical intercession. The…
This device allows for observation of single cells encapsulated in droplets and provide the ability to recover droplets containing a cell of interest. This system provides the unique capability to monitor droplet contents from a few minutes to hours and overcome the limitations of the fluorescence activated cell sorting (FACS) in the purification of cell populations. The ability of this…
This invention consists of a functionalized membrane (e.g. polyethylene glycol (PEG)) and osmosis or electric potential as a driving force. The PEG membrane provides high biological particles separation and prevents sample for clogging due to the strong hydration of functional polymers layer and their resistance to protein adsorption.
This invention is an improved chromatography device that utilizes the concept of a functionally graded material (FGM) for separation of components. The technology consists of a device that contains a FGM that is patterned to have a gradient in material properties (e.g. chemical affinity, surface chemistry, chirality, pore size, etc.) normal to the direction of flow of the mobile phase. The…
The art described here incorporates a planar integrated optical system that allows for multiple biochemical assays to be run at the same time or nearly the same time. Briefly, each assay can include one or more tags (e.g. dyes, other chemicals, reagents) whose optical characteristics change based on chemical characteristics of the biological sample being tested.
This technology describes a method for partitioning fluid into “packets” between polymeric sheets. The fluid to be partitioned is introduced between two polymeric layers or within a polymeric channel and the layers are sealed together to form an array or sequence of individual milliliter to picoliter samples as shown in figure below. This approach allows a continuous flow of samples through…
LLNL researchers have developed a variation of AMS technology that improves sample preparation, analysis, and cost for AMS. The device involves depositing liquid samples on an indented moving wire and passing the moving wire through a combustion oven to convert the carbon content of samples to carbon dioxide gas in a helium stream. The gas is then directed via a capillary to a high efficiency…
LLNL has invented a new high-throughput assay for sample separation that uses the vibrations of a piezoelectric transducer to produce acoustic radiation forces within microfluidic channels. The system includes a separation channel for conveying a sample fluid containing the different size particles, an acoustic transducer and a recovery fluid stream. The polymeric films containing the…
LLNL researchers have developed an apparatus capable of measuring and recording ultraviolet radiation that uses the Schottky diode/ZnSe/metal type UV sensor. This device can detect both UV-A (320-400nm) and UV-B(280-320nm) radiation. The present invention can also measure and accumulate doses with good sensitivity, and it can also store and make available the readings to be downloaded for…
The invention developed by LLNL researchers proposes to use staged isotachophoresis to improve sample separation. One of the problems with isotachophoresis is that there is a tradeoff between the diameter of the separation column and the ability to isolate a species into a detectable band. For example, wider diameter channels run faster, but narrower channels provide better ability to isolate…
LLNL researchers have devolved a technique to separate or purify samples using electrophoretic separation. This invention corrects the problem associated with pH changes by using the electrode, which contacts the sample, itself a high-conductivity electrolyte made of liquid or gel materials. This will keep the metal surface electrochemistry physically remote from the sample, while…
Researchers at LLNL have developed a more efficient and cost-effective method and system for synthesizing a critical D-aminoluciferin precursor and related compounds. D-aminoluciferin is as active as luciferin and provides a free -NH2 group for functionalization to attach peptide sequences corresponding to the cleavage site of a protease. This allows for the synthesis of bioluminescent probes…
LLNL's technology employs improved sorting strategies related to chip-based droplet sorting. This technology uses electromagnetic fields and non-contact methods to sort and identify monodispersed water-in-oil emulsion droplets in a microfluidic chip-based device. The system selects individual droplets from a continuous stream based on optical or non-optical detection methods as…
Researchers at LLNL have developed a method to passively sort individual microdroplet samples of uniform size based on stiffness and viscosity. Unlike electrical or optical methods for droplet sorting, this apparatus does not require a measurement step. Instead, particle separation occurs through changes in shearing forces determined by the stiffness of the particles in the microdroplet sample…
LLNL researchers have created a method that uses isotachophoresis for the exclusion and or purification of nucleic acids. Isotachopheresis (ITP) is an electrophoretic separation technique that leverages a heterogeneous buffer system of disparate electrophoretic mobilities. The researchers created a transverse ITP system that offers high-throughput sample preparation as the amount of sample…
The steady-state phenomenon generates thousands of microdroplets per second which is a problem when the stream of droplets needs to be slowed down or stopped. LLNL technology provides a method for generating and trapping microdroplets at a desired location and subsequently stopping the stream of microdroplets without droplet coalescence. These microdroplets can then be chemically reacted,…
The present invention uses magnetic fields to hold particles in place for faster DNA amplification and sequencing. This invention provides a method for faster DNA sequencing by amplification of the genetic material within microreactors, denaturing and de-emulsifying and then sequencing the material while retaining it in the PCR/sequencing zone by a magnetic field. Briefly, nucleic acid…
This invention is designed to sort and identify complex samples using parallel nucleic acid characterization. By isolating single or double stranded nucleic acids derived from complex samples, researchers can sequence previously unknown genetic material to identify novel viruses and organisms. The chip-based microfluidic system achieves this through microdroplet PCR amplification,…
This technology is a photonic detection system developed by researchers at LLNL for the detection of biological or chemical threats with the intention of combining the collection, concentration and detection process onto a single platform. The present invention consists of a porous membrane containing flow-through photonic silicon crystals (see figure).
The described invention is a miniature fluidic device for separating particles suspended within a liquid sample that is introduced into the interior volume of the device. The device uses laminar flow and a combination of gravity and acoustic, electrophoretic, dielectrophoretic, and diffusion-based processes in concert to separate the different particle types and allow them to be collected…
Researchers at LLNL have developed a nanotube sensor (single-walled or multi-walled carbon nanotubes) enclosed within a highly selective lipid bilayer that can detect variations in ion transport using signal amplification generated from the disruption of protein pores across the lipid layer. Changes in the device’s transistor current are recorded by an external circuit with high efficiency as…
Researchers at LLNL have created a new technology for performing pumping and valving operations in microfabricated fluidic systems. Traditional microfabricated devices have some disadvantages that defeat the advantages of miniaturization. For example, they require high power and voltage, and they need specific fluids to work properly and to be broadly applicable. The technology described here…
To solve these challenges using new and existing CT system designs, LLNL has developed an innovative software package for CT data processing and reconstruction. Livermore Tomography Tools (LTT) is a modern integrated software package that includes all aspects of CT modeling, simulation, reconstruction, and analysis algorithms based on the latest research in the field. LTT contains the most…
LLNL has a successful history of developing instruments for detecting and characterizing airborne pathogens. Often, aerosol characterizing instruments require highly focused particle beams with little or no transmission losses. In addition, they need to interface to the sampling environment with a very high sampling rate so that more aerosol particles can be collected and sensitivity can be…
LLNL scientists have designed a rapid PCR technology that incorporates the use of microfluidic thermal heat exchanger systems and is comprised of a porous internal medium, with two outlet channels, two tanks, and one or more exchanger wells for sample receiving. The wells and their corresponding inlet channels are coupled to two tanks that contain fluid with cold and hot temperatures. A…
LLNL has developed a new technology that provides a method for near-instantaneous heating of aqueous samples in microfluidic devices. The technology relates to a heating method that employs microwave energy absorption from a coincident low power Co-planar waveguide or microwave microstrip transmission line embedded in a microfluidic channel to instantaneously heat samples. The method heat…
Researchers at LLNL have developed an instantaneous sample heating method to efficiently deposit thermal energy into a continuous stream or segmented microdroplets on a MOEMS device using an optimally low energy, commercially available CO2 laser. The device uses an ideal wavelength (absorption in the far infra-red (FIR) region (λ=10.6 μm)) to instantaneously heat fluidic partitions. The…
Researchers at LLNL have designed a new technology that allows the integration of a large bench-top thermal cycling instrument onto a miniaturized instrument. This instrument is powered and controlled by portable thumb-drive systems such as an USB. USB thumb-drives are commonly used to transfer data from the instrument onto a PC, however, in this new technology the thumb drive becomes the…
This technology describes a method for performing immediate in-line sample heating to promote the required chemical reactions for amplification, activation, or detection, depending on the thermodynamics of the particular assay involved. The basis of this technology is a method that employ microwave energy absorption to instantaneously heat fluidic partitions without heating the device itself…
LLNL researchers have developed a new method for faster, more accurate, and precise thermal control for DNA amplification. This technology uses sensor-controlled nodes to monitor and cycle materials through a microfluidic heat exchanging system. Thermal energy travels from a power module through thermal electric elements to sample wells. Sensors coupled to each sample well monitor and respond…
The LLNL method is based on freeze‐casting of aerosolized and pressurized metal salt solutions and subsequent thermal processing. This method generates both porous particles with sizes down to one micron and macroscopic monoliths with nanometer scale ligaments/struts. The material's density can be controlled during the freeze‐dried stage. Compared to conventional approaches, this method…
LLNL has developed a liquid-free method that increases the overall mechanical resistance of self-supported, carbon nanotube assemblies through nanoscale reinforcement by gas-phase deposition of a thermally cross-linkable polymer. Polymer-reinforcement increases the strength of CNT yarns after crosslinking. For example, a minimal amount (<200 nm) of poly-glycidyl metacrylate (PGMA) deposited…
LLNL researchers have developed a novel method of 3D printing regular microstructured architectures and subsequent complex macrostructures from additively manufactured bio-based composite thermoset shape memory polymer composite materials. This technology for 3D additively manufactured parts utilizes up to a 4 axis control DIW system for fabricating bio based thermally cured epoxy based SMP…
LLNL researchers have developed the hardware and chemistry to allow additive manufacturing of short carbon fibers in a thermoset polymer matrix which have a high degree of structural alignment over conventional cast or pressed short/chopped carbon fiber polymer composites.
The invention is based on the shear dispersal, alignment and concentration of fiber fraction within a resin…
LLNL has developed a technology that provides near-instantaneous heating of aqueous samples in microfluidic devices. The method heats samples in a focused area within a microfluidic channel on miniaturized chips. The microwave heating device is composed of a waveguide or microstrip transmission line embedded in a microfluidic channel. Aqueous solution microwave heating allows extremely fast…
The biotech industry aims to move towards an on-chip system for sample generation, amplification and detection of both DNA and RNA based organisms. LLNL has invented a new way of isolating samples in a system.
This invention enables creation of partitioned fluid "packets" between polymeric sheets for chemical separation, DNA amplification or PCR-based DNA detection. The polymeric…
Dubbed the "LLNL Chemical Prism", the LLNL system has use wherever there is a need to separate components of a fluid. A few examples include:
- Chemical detection for known and previously unknown chemicals or substances
- Separation of biomolecules from a cellular extract
- Fractionation of a complex mixture of hydrocarbons
- Forensic analysis of…
Lawrence Livermore National Laboratory scientists have developed a signal enhancing microchip apparatus and method that enhances a microfluidic detector's limits by magnetically focusing the target analytes in a zone of optical convergence. In summary, samples are associated with magnetic nanoparticles or magnetic polystyrene coated beads and moved down the flow channels until they are trapped…
LLNL’s BioBriefcase is a compact and portable instrument capable of autonomously detecting the full spectrum of bioagents, including bacteria, viruses and toxins in the air. It uses the state of art technologies to collect, process, and analyze samples to detect, and identify genetic and protein signatures of bioagents.
Redox ion-exchange polymers ("redox-ionites") and membranes possessing cation- and anion- exchange, amphoteric, complex-forming and oxidation-reduction abilities have been developed on the basis of the biocompatible synthetic and chemically modified natural polymers. In addition, developments have been made towards methods of obtaining of water-soluble and spatially cross-linked ionites of…
This technology uses either of two X-ray wave-front sensor techniques, Hartmann sensing and two-dimensional shear interferometry, both of which are capable of measuring the entire two-dimensional electric field, both the amplitude and the phase, with a single measurement. Capturing both the absorption and phase coefficients of the index of refraction can help to reconstruct the image.…