LLNL researchers have designed and developed a novel high-density, high-channel count 3D connector that enables hundreds or thousands of nonpermanent connections within a compact footprint. The connector addresses limitations of currently used conventional approaches that were described previously, which have an artificial ceiling on the number of recording sites of modern devices of no more…
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![4D Computed Tomography Reconstructions](/sites/default/files/styles/scale_exact_400x400_/public/2024-05/4D%20Computed%20Tomography%20Reconstructions.png?itok=62nJWKhK)
LLNL’s Distributed Implicit Neural Representation (DINR) is a novel approach to 4D time-space reconstruction of dynamic objects. DINR is the first technology to enable 4D imaging of dynamic objects at sufficiently high spatial and temporal resolutions that are necessary for real world medical and industrial applications.
![CT Scanner Adobe Stock Image](/sites/default/files/styles/scale_exact_400x400_/public/2024-03/CT%20Scanner.jpeg?itok=tHCxNWpA)
The essence of this invention is a method that couples network architecture using neural implicit representations coupled with a novel parametric motion field to perform limited angle 4D-CT reconstruction of deforming scenes.
![Potential reactor configurations with printed TPMS scaffolds](/sites/default/files/styles/scale_exact_400x400_/public/2023-12/Reactor_Config_with_TPMS_scaffolds.png?itok=stDW7Z7n)
LLNL researchers have devised a set of design principles that facilitates the development of practical TPMS-based two fluid flow reactors.; included in the design are these new concepts:
![multi-spectral nondestructive characterization of in-shell tree nuts](/sites/default/files/styles/scale_exact_400x400_/public/2023-11/multi-spectral%20nondestructive%20characterization%20of%20in-shell%20tree%20nuts.png?itok=-W2LFRIH)
LLNL’s novel technology automates the inspection process by using a scanning system that captures data within the walnut shell without having to open the shell. The system output gives a visual image inside the walnut shell sufficient to evaluate and rate the quality of the walnut. The system uses a camara and radar that can capture data at a rapid rate. This improves speed and reliability…
![solid state streak detector](/sites/default/files/styles/scale_exact_400x400_/public/2023-10/Solid%20State%20Streak%20Detector.png?itok=4t6vjY-r)
The approach is to develop a solid-state X-ray imager based on the architecture of the Silicon Drift Detector (SDD) which uses a series of cathode strips on both sides of a silicon wafer to achieve bulk depletion and electron drift. The invention leverages this SDD functionality to achieve signal stretching of liberated charge carriers from X-Ray photons that converts the time domain into the…
![Filled (8,8) (left) and (15,15) (right) CNTs with [EMIM+][BF4- ] using SGTI with the proposed spliced soft-core potential (SSCP) approach](/sites/default/files/styles/scale_exact_400x400_/public/2023-10/Filled%20CNTs%20using%20SGTI.png?itok=Dy0ObN7i)
LLNL researchers have developed a novel simulation methodology using slow growth thermodynamic integration (SGTI) utilizing spliced soft-core interaction potential (SSCP). The approach to filling the molecular enclosures is a nonphysical one. Rather than filling the pores from the open ends this method creates steps in the algorithm that allow molecules to pass through the pore wall and…
![Schematic of LLNL’s Fast Image Acquisition System](/sites/default/files/styles/scale_exact_400x400_/public/2023-06/Fast%20Image%20Acqusition%20System.png?itok=HFyr-Goi)
LLNL’s novel approach is to use a continuous moving camera with a scan speed of >1 mm/sec and a frame rate of 100 frames per second. The key is to have a light source that flashes with a duration of one nanosecond, thus essentially freezing the image with no blur. Clear images of high resolution can then be captured through a high-magnification objective lens (reflection mode) or through…
![3DQ Concept: Use two 2D detectors to enable detection of 3D position for the same event.](/sites/default/files/styles/scale_exact_400x400_/public/2023-05/3DQ%20Concept.png?itok=hPgLZTTl)
LLNL’s approach to the development of a wide-field, three-dimensional quantum (3DQ) microscope is to harness quantum entangled photons to form simultaneous 3D optical images, which could be a new paradigm for 3D volumetric imaging of biological specimens. The 3DQ microscope is comprised of a novel optical system with highly sensitive detectors and an on-demand light source of entangled…
![The image is a montage of an artist’s depiction of a liposomal drug carrier studded with carbon nanotube porins that is docking to a cancer cell surface and delivering chemotherapy cargo with a fluorescence microscopy image of stained cells exposed to these carriers. The red stain indicates that the cells are dead and the treatment was successful. Images by P. Lastrico of MPI and N.T. Ho and A. Noy of LLNL.](/sites/default/files/styles/scale_exact_400x400_/public/2023-05/liposomal%20drug%20carrier%20with%20CNT%20porins.jpg?itok=HvCCyUTI)
To address shortcomings of current liposome drug delivery systems, the patented innovation uses drug-loaded liposomes containing carbon nanotube porins (CNTPs) inserted into the liposomal membranes for the delivery of the encapsulated drugs. Short CNTPs (10 nm in length) with narrow diameter (0.8 nm) has been demonstrated to facilitate efficient fusion of lipid bilayers resulting in the…
![SEM image of iron-sulfide spheres](/sites/default/files/styles/scale_exact_400x400_/public/2023-05/iron-sulfide%20spheres.jpg?itok=X03OXhag)
A new approach of developing synthetic antibacterial mineral assemblages can be used as an alternative treatment when traditional antibiotics fail in clinical and agricultural settings. Mineral mixtures can be synthesized with tunable metal release and reactive oxygen species generation that are capable of killing human pathogens and promoting wound healing. One of the key components in the…
![novel thiacrown ethers for isolating of 197gHg and 197m,gHg](/sites/default/files/styles/scale_exact_400x400_/public/2023-05/novel%20thiacrown%20ether.png?itok=afjvUtSX)
The method described in a pending patent application uses a novel thiacrown (dibenzohexathia-18-crown-6) for efficient extraction of 197m,gHg and 197gHg from irradiated Pt target foils. The separation of 197m,gHg and 197gHg from Pt foils using this novel thiacrown was found to be highly specific. No detectable amount of the Pt foil was seen in the…
![High Density Protein Translation System: Nanotubes used to greatly increase the density of ribosomes on a surface by adding a third dimension (height) to enable multiple ribosomal attachment sites.](/sites/default/files/styles/scale_exact_400x400_/public/2023-04/High%20Density%20Protein%20Translation%20System.png?itok=zerUPjta)
Combining the principles of nanotechnology, cell-free protein synthesis and microfluidics, LLNL researchers have developed a reusable, portable programmable system that can create purified, concentrated protein product in vitro in a microfluidic device containing nucleic acids.
![Schematic of high density detachable electrical interfaces with a single layer](/sites/default/files/styles/scale_exact_400x400_/public/2023-04/High%20density%20detachable%20interface_single.png?itok=HqwlqXwl)
Many of the disadvantages of current interface devices can be overcome with LLNL’s novel interface design, which relies on area array distribution where independent interface connector subassemblies are positioned in a planar grid. Not only is the interface device expandable area-wise (without increasing contact force), but it could also be expanded height-wise, with multiple layers of these…
![Flexible optoelectronic chip with integrated transmitter and receiver subassemblies](/sites/default/files/styles/scale_exact_400x400_/public/2023-04/Flexible_optoelectronic_chip.png?itok=EVf8ujMo)
Commercial fiber optic cables are the current standard for carrying optical signals in industries like communications or medical devices. However, the fibers are made of glass, which do not have favorable characteristics for applications that require flexibility and re-routing, e.g. typically brittle, limited selection of materials, dimension constraints.
![Livermore Tomography Tools LTT](/sites/default/files/styles/scale_exact_400x400_/public/2022-06/LTT.jpg?itok=cQE9Kpef)
To solve these challenges using new and existing CT system designs, LLNL has developed an innovative software package for CT data processing and reconstruction. Livermore Tomography Tools (LTT) is a modern integrated software package that includes all aspects of CT modeling, simulation, reconstruction, and analysis algorithms based on the latest research in the field. LTT contains the most…
![blue bacteria](/sites/default/files/styles/scale_exact_400x400_/public/2022-07/blue%20bacteria.jpg?itok=ddcclBXg)
LLNL scientists developed novel hydrogels, which are biodegradable soft materials synthesized by a water-soluble polymer. Incorporating silver imparts antimicrobial activity to the material at low concentration compared to currently used silver nanoparticles. Our hydrogels are composed of silver ions instead of silver nanoparticles, which eliminates the toxicity concerns of modern silver…
![Livermore Tomography Tools LTT](/sites/default/files/styles/scale_exact_400x400_/public/2022-06/LTT.jpg?itok=cQE9Kpef)
LLNL's 3D X-ray imager combines two different hardware pieces. The first is an x-ray optic with a depth-of-field that is small compared to the object under investigation. Reflective Wolter type x-ray optics are one such design. These hollow optics have a relatively large collection efficiency and can be designed with a large field of view. The depth of focus, which is the distance over which a…
![Nanoporus gold](/sites/default/files/styles/scale_exact_400x400_/public/2022-06/nanoporus%20gold%20875x500.jpg?itok=A0gFmVPT)
By combining 3D printing and dealloying., researchers at LLNL have developed a method for fabricating metal foams with engineered hierarchical architectures consisting of pores at least 3 distinct length scales. LLNL’s method uses direct ink writing (DIW), a 3D printing technique for additive manufacturing to fabricate hierarchical nanoporous metal foams with deterministically controlled 3D…
![iChip, brain on a chip](/sites/default/files/styles/scale_exact_400x400_/public/2022-07/iChip.jpg?itok=B-rQJQjn)
LLNL has developed a brain-on-a-chip system with a removable cell-seeding funnel to simultaneously localize neurons from various brain regions in an anatomically relevant manner and over specific electrode regions of a MEA. LLNL’s novel, removable cell seeding funnel uses a combination of 3D printing and microfabrication that allows neurons from select brain regions to easily be seeded into…
![energy_absorbing_material.jpg energy_absorbing_material](/sites/default/files/styles/scale_exact_400x400_/public/2019-08/energy_absorbing_material.jpg?itok=UxNZ6nWH)
To overcome limitations with cellular silicone foams, LLNL innovators have developed a new 3D energy absorbing material with tailored/engineered bulk-scale properties. The energy absorbing material has 3D patterned architectures specially designed for specific energy absorbing properties. The combination of LLNL's capabilities in advanced modeling and simulation and the additive…
![Marine helmet](/sites/default/files/styles/scale_exact_400x400_/public/2022-06/Marine%20helmet-inside.jpg?itok=8W_dqpgI)
LLNL's high fidelity hydrocode is capable of predicting blast loads and directly coupling those loads to structures to predict a mechanical response. By combining this code and our expertise in modeling blast-structure interaction and damage, along with our access to experimental data and testing facilities, we can contribute to the design of protective equipment that can better mitigate the…