Image

Lawrence Livermore National Laboratory (LLNL) is offering the opportunity to collaborate in accelerating artificial intelligence (AI) for applied science, including research in key areas such as advanced material design, 3D printing, predictive biology, energy systems, “self-driving” lasers and fusion energy research.…

Image

The Lawrence Livermore National Laboratory Surface Complexation Database Converter (SCDC) is a R-based script that creates a unified dataset of surface complexation experimental data with respective parameters and results. To provide context, it is commonly understood in the data science community that gathering and cleansing data can take up to 80% of the time in analytics - with the…

Image
CRETIN is a 1D, 2D, and 3D non-local thermodynamic equilibrium (NLTE) atomic kinetics/radiation transport code which follows the time evolution of atomic populations and photon distributions as radiation interacts with a plasma consisting of an arbitrary mix of elements. It can provide detailed spectra for comparing with experimental diagnostics.
Image

Autopack is an open-source python tool that enables the automatic labeling of packing motifs for large and chemically diverse datasets of molecular crystals. Autopack takes advantage of geometric descriptors to find useful cross-sections within the crystal structure to elucidate the associated packing motif. Autopack is capable of processing either crystallographic information files (CIFs) or…

Image

LLNL has developed a method of extending device lifetimes by imprinting into the device a shape that excludes specific vibrational modes, otherwise known as a phononic bandgap. Eliminating these modes prevents one of the primary energy loss pathways in these devices. LLNL’s new method enhances the coherence of superconducting circuits by introducing a phononic bandgap around the system’s…

Image

LLNL is seeking industry partners to collaborate on quantum science and technology research and development in the following areas: quantum-coherent device physics, quantum materials, quantum–classical interfaces, computing and simulation, and sensing and detection.

Image

Solid-state distributed node-based rapid thermal cycler for extremely fast nucleic acid amplification (LLNL Internal Case # IL-12275, US Patent

Image

Laser heating of aqueous samples on a micro-optical-electro-mechanical system (LLNL Internal Case # IL-11719, US Patents

Image

LLNL researchers have designed a synthetic, concatemeric bacterial expression vector that expresses a protein sequence that can be digested into a single peptide. The synthetic protein is designed to be secreted outside E. coli cells, and therefore can be purified using a His-tag from the cell supernatant (thereby reducing the need to lyse the cells for…

Image

LLNL scientists have created a technology that utilizes electrical means, instead of optical methods, to (1) provide label-free detection of droplet morphology; (2) manipulate droplet position through trapping and actuation; (3) track individual droplets in a heterogeneous droplet population; and (4) generate droplets with target characteristics automatically without optical…

Image

This device allows for observation of single cells encapsulated in droplets and provide the ability to recover droplets containing a cell of interest. This system provides the unique capability to monitor droplet contents from a few minutes to hours and overcome the limitations of the fluorescence activated cell sorting (FACS) in the purification of cell populations.…

Image

This invention consists of a functionalized membrane (e.g. polyethylene glycol (PEG)) and osmosis or electric potential as a driving force. The PEG membrane provides high biological particles separation and prevents sample for clogging due to the strong hydration of functional polymers layer and their resistance to protein adsorption.…

Image

This invention is an improved chromatography device that utilizes the concept of a functionally graded material (FGM) for separation of components. The technology consists of a device that contains a FGM that is patterned to have a gradient in material properties (e.g. chemical affinity, surface chemistry, chirality, pore size, etc.) normal to the direction of flow of the…

Image

The art described here incorporates a planar integrated optical system that allows for multiple biochemical assays to be run at the same time or nearly the same time. Briefly, each assay can include one or more tags (e.g. dyes, other chemicals, reagents) whose optical characteristics change based on…

Image

This technology describes a method for partitioning fluid into “packets” between polymeric sheets. The fluid to be partitioned is introduced between two polymeric layers or within a polymeric channel and the layers are sealed together to form an array or sequence of individual milliliter to picoliter samples as shown in figure below. This approach allows a…

Image

LLNL researchers have developed a variation of AMS technology that improves sample preparation, analysis, and cost for AMS. The device involves depositing liquid samples on an indented moving wire and passing the moving wire through a combustion oven to convert the carbon content of samples to carbon dioxide gas in a helium stream. The gas is then directed via a capillary to…

Image

LLNL has invented a new high-throughput assay for sample separation that uses the vibrations of a piezoelectric transducer to produce acoustic radiation forces within microfluidic channels. The system includes a separation channel for conveying a sample fluid containing the different size particles, an acoustic transducer and a recovery fluid stream. The polymeric…

Image

LLNL researchers have developed an apparatus capable of measuring and recording ultraviolet radiation that uses the Schottky diode/ZnSe/metal type UV sensor. This device can detect both UV-A (320-400nm) and UV-B(280-320nm) radiation. The present invention can also measure and accumulate doses with good sensitivity, and it can also store and make available the readings to be…

Image

The invention developed by LLNL researchers proposes to use staged isotachophoresis to improve sample separation. One of the problems with isotachophoresis is that there is a tradeoff between the diameter of the separation column and the ability to isolate a species into a detectable band. For example, wider diameter channels run faster, but narrower channels provide better…

Image

LLNL researchers have devolved a technique to separate or purify samples using electrophoretic separation. This invention corrects the problem associated with pH changes by using the electrode, which contacts the sample, itself a high-conductivity electrolyte made of liquid or gel materials. This will keep the metal surface electrochemistry physically remote from the sample,…

Image

Researchers at LLNL have developed a more efficient and cost-effective method and system for synthesizing a critical D-aminoluciferin precursor and related compounds. D-aminoluciferin is as active as luciferin and provides a free -NH2 group for functionalization to attach peptide sequences corresponding to the cleavage site of a protease. This allows for the synthesis of…

Image

LLNL's technology employs improved sorting strategies related to chip-based droplet sorting. This technology uses electromagnetic fields and non-contact methods to sort and identify monodispersed water-in-oil emulsion droplets in a microfluidic chip-based device. The system selects individual droplets from a continuous stream based on optical or non-optical detection…

Image

Researchers at LLNL have developed a method to passively sort individual microdroplet samples of uniform size based on stiffness and viscosity. Unlike electrical or optical methods for droplet sorting, this apparatus does not require a measurement step. Instead, particle separation occurs through changes in shearing forces determined by the stiffness of the particles in the…

Image

LLNL researchers have created a method that uses isotachophoresis for the exclusion and or purification of nucleic acids. Isotachopheresis (ITP) is an electrophoretic separation technique that leverages a heterogeneous buffer system of disparate electrophoretic mobilities. The researchers created a transverse ITP system that offers high-throughput sample preparation as the amount…

Image

The steady-state phenomenon generates thousands of microdroplets per second which is a problem when the stream of droplets needs to be slowed down or stopped. LLNL technology provides a method for generating and trapping microdroplets at a desired location and subsequently stopping the stream of microdroplets without droplet coalescence. These microdroplets can then be…

Image

Proteins and other functional molecules can often be synthesized in significant quantities, but their purification presents challenges. Also, many chemical/biological sensor technologies require that a small number of nanometer-sized molecules be filtered prior to being exposed to molecular recognition chemistries.

Image

The present invention uses magnetic fields to hold particles in place for faster DNA amplification and sequencing. This invention provides a method for faster DNA sequencing by amplification of the genetic material within microreactors, denaturing and de-emulsifying and then sequencing the material while retaining it in the PCR/sequencing zone by a magnetic field.…

Image

This invention is designed to sort and identify complex samples using parallel nucleic acid characterization. By isolating single or double stranded nucleic acids derived from complex samples, researchers can sequence previously unknown genetic material to identify novel viruses and organisms. The chip-based microfluidic system achieves this through microdroplet PCR amplification,…

Image

This technology is a photonic detection system developed by researchers at LLNL for the detection of biological or chemical threats with the intention of combining the collection, concentration and detection process onto a single platform. The present invention consists of a porous membrane containing flow-through photonic silicon crystals (see figure).

Image

The described invention is a miniature fluidic device for separating particles suspended within a liquid sample that is introduced into the interior volume of the device. The device uses laminar flow and a combination of gravity and acoustic, electrophoretic, dielectrophoretic, and diffusion-based processes in concert to separate the different particle types and allow them to be…

Image

Researchers at LLNL have developed a nanotube sensor (single-walled or multi-walled carbon nanotubes) enclosed within a highly selective lipid bilayer that can detect variations in ion transport using signal amplification generated from the disruption of protein pores across the lipid layer. Changes in the device’s transistor current are recorded by an external circuit with high…

Image

Researchers at LLNL have created a new technology for performing pumping and valving operations in microfabricated fluidic systems. Traditional microfabricated devices have some disadvantages that defeat the advantages of miniaturization. For example, they require high power and voltage, and they need specific fluids to work properly and to be broadly applicable. The technology…

Image

Livermore Lab researchers have developed a new EUV target design that replaces liquid tin droplets with tin microbeads embedded in a low Z tamping fluid. The use of low Z liquid tamped targets can solve several problems that are currently faced by the industry. It can increase the total operational uptime from 80% to close to 100%. It can simplify EUV source design and reduce…

Image

Researchers at LLNL have invented a new method for forming microfluidic system platforms that allow the incorporation of various microfluidic devices into a single unit. The method involves creating channels, reservoirs, and ports using a polymer-based platform that allows for the interconnection of building blocks. Pre-fabricated structures such as T’s and elbows are used to…

Image
Researchers at LLNL have developed a new method to utilize highly selective molecular recognition events to attach proteins to any solid support through the C-terminus. The approach is based on the use of protein trans-splicing, which is a naturally occurring process similar to protein splicing with the difference that the intein (e.g., DnaE intein from Synechocystis sp. PCC6803) self-processing…
Image

To solve these challenges using new and existing CT system designs, LLNL has developed an innovative software package for CT data processing and reconstruction. Livermore Tomography Tools (LTT) is a modern integrated software package that includes all aspects of CT modeling, simulation, reconstruction, and analysis algorithms based on the latest research in the field. LTT contains the most…

Image
Versatile Cold Spray (VCS) enables deposition of brittle materials, such as thermoelectrics, magnets, and insulators, while retaining their functional properties. Materials can be deposited on substrates or arbitrary shapes with no requirement to match compositions. The VCS system is low cost, easily portable, and easy to use. VCS has been developed in a collaboration between Lawrence Livermore…
Image

In order to identify new, unknown proteins associated with viruses, such as COVID-19, it is easiest to start by identifying structurally related proteins. LLNL scientists have created tools that identify structurally related proteins and their relevant residues, called cSpan. The cSpan (sequence conservation in structurally conserved “span” regions) calculation is a quantitative measure of…

Image

Understanding proteins, their structures, and how they may be similar is necessary for many applications from basic science to developing vaccines for COVID-19. Most computational models that predict protein structure similarity consider certain features at the expense of others. To get a holistic picture of protein structures, LLNL scientists developed the Local-Global Alignment (LGA) model.…

Image

Automating protein classification via structural similarity has been a technique employeed by researchers for a while. The current methods generally only assess structure similarity using a single metric (e.g., Z-score) and only evaluate similar conformations of secondary structure elements. In order to accurately access structure similarity, LLNL scientists created a method called STRucture…

Image

Understanding how proteins interact with membrane surfaces is important for drug discovery studies in which a drug may target a membrane protein. One of the main proteins of interest for COVID-19 antibodies is the ACE2 protein that binds to the neutral amino acid transporter B0AT1. B0AT1 sits in the membrane and understanding how movement or perturbation of that membrane might after the…

Image

Communicating complex scientific information is a critical activity in responding to today’s COVID-19 pandemic. Many sources exist now to present trustworthy and timely information in ways that decisionmakers and the general public can understand. One way to communicate scientific information is to show the technical data in visual forms that users can easily relate to and interact with. LLNL’…

Image

One of the biggest challenges in many fields of studies, such as COVID-19, is to analyze a complex mix of experimental and simulation data, which relies primarily on the intuition of trained experts. Many advanced analysis techniques are often difficult to integrate, leading to a confusing patchwork of analysis snippets too cumbersome for data exploration. To simplify data analysis, LLNL…

Image

Computed tomography (CT) is one of the most common imaging modalities used in industrial, healthcare, and security settings. During a CT scan, a narrow beam of x-rays is used to produce signals that are processed by a computer to generate cross-sectional images of a part of the human body, such as the lungs of a suspected COVID-19 patient or a patient in recovery needing long-term…

Image

Cardiotoxicity is one of the major toxicity concerns when developing new drugs. However, these cardiotoxicity tests aren’t done until a drug has gone through years of development. LLNL scientists have developed a software suite called Cardioid that simulates the electrical current running through the heart tissue, triggering cells to contract like cascading dominoes and causing the heart to…

Image

Protective equipment has always been central to keeping our military, first responders and medical personnel safe. The COVID-19 pandemic is a sobering reminder of the importance of such equipment and the need for improvements. A team lead by LLNL has developed a smart, breathable fabric designed to be incorporated into a garment in small patches to protect the wearer against biological and…

Image

Analyzing the performance and efficiency of complex facilities with modern instrumented components – and the performance of regional networks of such facilities - is a daunting task. Increasingly, facilities collect data from manually input systems as well as diverse Internet of Things sensors and monitoring tools for specialty equipment, storage systems, computing networks, and power/cooling…

Image

Complex problems, such as COVID-19, are being studying computational, prior to be tested experimentally. These complex computational problems require HPC resources, of which must be understood and allocated properly. This requires the user to waste valuable computational time just setting up a job on the HPC system. In order to allow computational scientists to focus on the science, LLNL…

Image

To understand complex problems using machine learning it is generally necessary to have large amounts of data. In order to generate these large amounts of data, researchers utilize simulation. Simulations are best run on High-Performance Computers (HPCs) which require various complex processes. To simplify running machine learning based workflows on HPCs, LLNL scientists developed Merlin. The…

Image

LLNL has a successful history of developing instruments for detecting and characterizing airborne pathogens. Often, aerosol characterizing instruments require highly focused particle beams with little or no transmission losses. In addition, they need to interface to the sampling environment with a very high sampling rate so that more aerosol particles can be collected and sensitivity can be…

Image

In 2005, LLNL researchers won a R&D 100 award for developing advanced technologies to rapidly detect the airborne release of biological threat agents. The Biological Aerosol Mass Spectrometry (BAMS) system is an instrument about the size of three podiums that can analyze individual aerosol particles in real time and at high rates to almost instantly identify the presence and concentration…

Image

LLNL scientists have designed a rapid PCR technology that incorporates the use of microfluidic thermal heat exchanger systems and is comprised of a porous internal medium, with two outlet channels, two tanks, and one or more exchanger wells for sample receiving. The wells and their corresponding inlet channels are coupled to two tanks that contain fluid with cold and hot temperatures. A…

Image

LLNL has developed a new technology that provides a method for near-instantaneous heating of aqueous samples in microfluidic devices. The technology relates to a heating method that employs microwave energy absorption from a coincident low power Co-planar waveguide or microwave microstrip transmission line embedded in a microfluidic channel to instantaneously heat samples. The method heat…

Image

Researchers at LLNL have developed an instantaneous sample heating method to efficiently deposit thermal energy into a continuous stream or segmented microdroplets on a MOEMS device using an optimally low energy, commercially available CO2 laser. The device uses an ideal wavelength (absorption in the far infra-red (FIR) region (λ=10.6 μm)) to instantaneously heat fluidic partitions. The…

Image

Researchers at LLNL have designed a new technology that allows the integration of a large bench-top thermal cycling instrument onto a miniaturized instrument. This instrument is powered and controlled by portable thumb-drive systems such as an USB. USB thumb-drives are commonly used to transfer data from the instrument onto a PC, however, in this new technology the thumb drive becomes the…

Image

LLNL researchers have developed a high-volume, low-cost diagnostic test that is easy to use and provides results in under an hour. The testing platform will provide emergency responders and other medical professionals with the ability to screen individuals using oral and nasal samples, and obtain results in approximately 30 minutes. This point-of-care testing approach will enable rapid triage…

Image

This technology describes a method for performing immediate in-line sample heating to promote the required chemical reactions for amplification, activation, or detection, depending on the thermodynamics of the particular assay involved. The basis of this technology is a method that employ microwave energy absorption to instantaneously heat fluidic partitions without heating the device itself…

Image

LLNL researchers have developed a new method for faster, more accurate, and precise thermal control for DNA amplification. This technology uses sensor-controlled nodes to monitor and cycle materials through a microfluidic heat exchanging system. Thermal energy travels from a power module through thermal electric elements to sample wells. Sensors coupled to each sample well monitor and respond…

Image

Natural Language Processing (NLP) is a field of study which aims to program computers to process and analyze large amount of natural language data. In order to accurately and effectively utilize datasets in NLP systems, labeled datasets are a must. In cases like pathology reports, the sub-parts of the report are not programmatically labeled. To solve the unlabeled dataset problem, LLNL…

Image

Conventional dimension reduction methods aim to maximally preserve the global and/or local geometric structure of a dataset. However, in practice one is often more interested in determining how one or multiple user-selected response function(s) can be explained by the data. To intuitively connect the responses to the data, LLNL scientists developed function preserving projections (FPP), a…

Image

Clinical images have a wealth of data that are currently untapped by physicians and machine learning (ML) methods alike. Most ML methods require more data than is available to sufficiently train them. In order to obtain all data contained in a clinical image, it is imperative to be able to utilize multimodal, or various types of, data such as tags or identifications, especially where spatial…

Image

Some COVID-19 diagnoses are utilizing computed tomography (CT)-scans for triage. CT-scans produce immediate results with high sensitivity. The digital images produced by a CT-scan require physicians to identify objects within the image to determine the presence of disease. Object identification can be done using machine learning (ML) techniques such as deep learning (DL) to improve speed and…

Image

Drug discovery could be significantly sped up by the integration of in silico methods. To this end, LLNL scientists along with other ATOM Consortium members created the ATOM Modeling PipeLine (AMPL). AMPL is an open-source, modular, extensible, end-to-end software pipeline for building and sharing models. It extends the functionality of DeepChem and supports an array of machine learning and…

Image

When analyzing a dataset, one must not only understand the relationship between the data points, but also the underlying structure of the set. The underlying structure of a dataset is generally estimated from the data on hand, leading to assumptions and less accurate predictions. In order to improve structure learning, LLNL scientists have developed an open source software suite called MTL.…

Image

There are prominent technical challenges arising from spinning a battery on the order of kilohertz as required by magic angle spinning in order to obtain spectral resolution that are addressed and enable operando solid-state NMR. The operando NMR measurement allows for continuous monitoring of the battery components and of potential metastable states that may exist during…

Image

The innovators have modified a epoxide-assisted sol-gel method to produce chlorine-free, monolithic REO aerogels in just a matter of hours. This method was demonstrated for the lanthanide series. An important factor in realizing the sol-gel transition with the nitrate precursor was the addition of a key ingredient and moderate heat.. These alcogels can then be dried and calcined to produce…

Image

MimicGAN represents a new generation of methods that can “self-correct” for unseen corruptions in the data out in the field. This is particularly useful for systems that need to be deployed autonomously without needing constant intervention such as Automated Driver Assistance Systems. MimicGAN achieves this by treating every test sample as “corrupt” by default. The goal is to determine (a) the…

Image
The team’s prototype is intended to be safe, simple and easy to build, while still achieving the minimally required functionality necessary to treat patients with COVID-19. The ventilator has two functional air flow circuits: an inhalation and an exhalation circuit (Figure 1). The pressure in each circuit—Peak Inspiratory Pressure (PIP) and Positive End-Expiratory Pressure (PEEP)—are controlled…
Image

Livermore Lab researchers have developed a tunable shaped charge which comprises a cylindrical liner commonly a metal such as copper or molybdenum but almost any solid material can be used and a surround layer of explosive in which the detonation front is constrained to propagate at an angle with respect to the charge axis.  The key to the concept is the ability to deposit a…

Image

LLNL scientists developed novel hydrogels, which are biodegradable soft materials synthesized by a water-soluble polymer. Incorporating silver imparts antimicrobial activity to the material at low concentration compared to currently used silver nanoparticles. Our hydrogels are composed of silver ions instead of silver nanoparticles, which eliminates the toxicity concerns of modern silver…

Image
Livermore Lab researchers have developed two new methods for improving the efficiency of laser drilling. The first method is based on multi-pulse laser technology. Two synchronized free-running laser pulses from a tandem-head Nd:YAG laser and a gated CW laser are capable of drilling through 1/8-in-thick stainless-steel targets at a standoff distance of 1 m without gas-assist. The combination of a…
Image
Livermore researchers have developed a method for implementing closed-loop control in extrusion printing processes by means of novel sensing, machine learning, and optimal control algorithms for the optimization of printing parameters and controllability. The system includes a suite of sensors, including cameras, voltage and current meters, scales, etc., that provide in-situ process monitoring…
Image

LLNL researchers have developed a portable device which analyzes one or multiple types of body fluids or gases to test for one or more medical conditions. A bodily fluid (such as blood, perspiration, saliva, breath, or urine) is put into a condenser surface and is then separated into both a primarily gas fluid component and a second one that is primarily liquid. These two samples from the same…

Image

The LLNL invention has two assay chambers wherein each chamber is comprised of another two chamber modules. This allows the device to process up to two assays per chamber module, or four total assays per biological sample. These two duplex assays are each fed by parallel interrogation ports while the device still maintains a small physical profile. Each port has its own LED for excitation,…

Image

LLNL researchers have discovered unique DNA signatures that can be used to identify, with high specificity, three such organisms with bio-weapon potential, including Yersinia pestis and Francisella tularensis (both Category A agents), and Brucella species (Category B agent). The DNA sequence information of a desired region of an organism unique to that organism is recorded, a DNA primer is…

Image

LLNL scientists have invented a method that is able to identify SE specific sequences that can be utilized as diagnostics markers. The method, called suppression subtractive hybridization (SSH), is a PCR-based technique that identifies restriction fragments that are present in the target strain but not other strains. A set of restriction enzymes specific to the target species isolates their…

Image

LLNL scientists have developed a battery-powered device which is low-cost and multi-chambered for the extraction and amplification of nucleic acids from environmental, clinical, and laboratory samples via loop-mediated isothermal amplification (LAMP). This platform identifies pathogenic bacteria and assists in determining the optimal treatment plan. A multi-chamber amplification cartridge in…

Image

LLNL scientists have developed a method to synthesize long DNA sequences of varying length starting from short oligos. Synthetic oligos are generated using bioinformatics tools by overlapping multiple small segments, such as 4-mers or 6-mers, derived from both strands of the source DNA strand. DNA polymerases fill the gaps between these short n-mers to create the new, longer DNA strand. This…

Image

LLNL scientists have created a standalone pathogen identifier that can be placed in public settings, such as in stores or on street corners. Not unlike an ATM in physical size, this kiosk will accept biological samples from an individual for multiplexed analysis. The sample collection process will be sufficiently simple such that anyone could begin the diagnostic process after making the…

Image

LLNL researchers have invented a system for identifying all known and unknown pathogenic or non-pathogenic organisms in a sample. This invention takes a complex sample and generates droplets from it. The droplets consist of sub-nanoliter volume reactors which contain the organism sized particles. A lysis device lyses the organisms and releases the nucleic acids. An amplifier then magnifies the…

Image

LLNL researchers have developed a method to quickly and accurately identify the family of a virus infecting a vertebrate via PCR. Universal primer sets consisting of short nucleic acid strands of 7 to 30 base pairs in length were created to amplify target sequences of viral DNA or RNA. These primers can amplify certain identifying sequences of all viral genomes sequenced to date as well as…

Image

LLNL scientists have developed a method to ensure the accuracy of that tomographic image by applying adaptive optics (AO) to OCT in a single instrument (AO-OCT). AO stabilizes the image being captured by the OCT device by utilizing a Hartmann-Shack wavefront sensor and a deformable mirror, a type of mirror designed to compensate for detected waveform abnormalities (such as ones caused by a…

Image

LLNL scientists have developed a rapid parallel genetic profiling technology that can be used to detect an array of pathogens from a small, complex sample. Detectable pathogens by the LLNL technology include viruses, bacteria, protozoa, and other microbes. The device works by first splitting a given sample into millions of emulsified, encapsulated microdroplets each of which are then split…

Image

LNLL scientists have invented a method for multiplexed detection of PCR amplified products which can be completed in a single step. Highly validated species-specific primer sets are used to simultaneously amplify multiple diagnostic regions unique to each individual pathogen. Resolution of the mix of amplified products is achieved by PCR product hybridization to corresponding probe sequences,…

Image

LLNL scientists have developed a technology which fulfills this need. The LLNL technology itself is comprised of two elements which are to be embedded in a user's personal electronic device (e.g. cell phone, tablet device, pager, etc.). The first is a proximity monitor which transmits location and temporal data such as the distance between the user and a contagious individual and the duration…

Image

This LLNL-developed invention is multiplexed and utilizes the Luminex bead-based liquid array, which contains 100 different unique beads. Oligonucleotide probes with sequences complementary to the target sequences are covalently coupled to these unique beads. These capture beads are mixed with viral samples obtained from the patient via cheek swabbing or a throat wash and subjected to PCR in a…

Image

LLNL scientists have developed a high-confidence, real-time multiplexed reverse transcriptase PCR (RT-PCR) rule-out assay for foot and mouth disease virus (FMDV). It utilizes RT-PCR to amplify both DNA and RNA viruses in a single assay to detect FMDV as well as rule out other viruses that cause symptoms in livestock indistinguishable from those caused by FMDV, such as Bovine Herpes Virus-1 (…

Image

Livermore Lab's SBC grating optics benefit from the combination of the following key technologies:

  • LLNL proprietary optical coating designs utilizing >100 thin film layers – enables ultra-low-loss, ppm transmission levels through the coating, high diffraction efficiency, and large bandwidth.
  • LLNL proprietary dispersive surface relief structure design –…
Image

The LiDO code combines finite element analysis, design sensitivity analysis and nonlinear programming in a High-Performance Computing (HPC) environment that enables the solution of large-scale structural optimization problems in a computationally efficient manner. Currently, the code uses topology optimization strategies in which a given material is optimally distributed throughout the domain…

Image

Using native bacterial regulatory systems, LLNL researchers have developed whole-cell biosensors that can be used in aqueous samples for sensitive and selective in situ detection of the uranyl oxycation (UO22+), the most toxic and stable form of U in oxygenated environments. Specifically, two functionally independent, native U-responsive regulatory systems, UzcRS and UrpRS, were integrated…

Image

Livermore Lab researchers have developed a method that combines additive manufacturing (AM) with an infill step to render a final component which is energetic. In this case, AM is first used to print a part of the system, and this material can either be inert or energetic on its own. A second material is subsequently added to the structure via a second technique such as casting, melt…

Image

Recent advancements in additive manufacturing, also called 3D printing, allow precise placement of materials in three dimensions. LLNL researchers have invented mechanical logic gates based on flexures that can be integrated into the microstructure of a micro-architected material through 3D printing. The logic gates can be combined into circuits allowing complex logic operations to be…

Image

LLNL's 3D X-ray imager combines two different hardware pieces. The first is an x-ray optic with a depth-of-field that is small compared to the object under investigation. Reflective Wolter type x-ray optics are one such design. These hollow optics have a relatively large collection efficiency and can be designed with a large field of view. The depth of focus, which is the distance over which a…

Image

LLNL researchers have invented a method for scaling the average power of high-energy solid-state lasers to high values of average output power while maintaining high efficiency. This method combines the gas-cooled-slab amplifier architecture with a pattern of amplifier pumping and extraction that is new to high-energy pulsed lasers, in which pumping is continuous and in which only a small…

Image

Livermore researchers have developed a chip slapper consisting of a substrate with a conductive bridge layer and a flyer layer on one side of the substrate. The other side of the substrate consists of conductive pads. The bridge side of the substrate is electrically connected to the pad side of the substrate through a conductive pathway. The design and shape of the conductive bridge is…

Image

Livermore researchers have developed two novel TiCl4 based non-alkoxide sol-gel approaches for the synthesis of SiO2/TiO2 nanocomposite aerogels. Composite SiO2-TiO2 aerogels were obtained by epoxide-assisted gelation (EAG route) of TiCl4/DMF solution in the presence SiO2 aerogel particles. Additionally, the same TiCl4/DMF solution was employed to prepare SiO2@TiO2 aerogels by a facile one-…

Image

LLNL pioneered the use of tomographic reconstruction to determine the power density of electron beams using profiles of the beam taken at a number of angles. LLNL’s earlier diagnostic consisted of a fixed number of radially oriented sensor slits and required the beam to be circled over them at a fixed known diameter to collect data. The new sensor design incorporates annular slits instead,…

Image

LLNL researchers have developed a new method of using silver nanowires for fabrication of ultralight conductive silver aerogel monoliths with predicable densities and excellent properties. Silver nanowire building blocks were prepared by polyol synthesis and purified by selective precipitation. Silver aerogels were produced by freeze-casting nanowire aqueous suspensions followed by thermal…

Image

LLNL uses the additive manufacturing technique known as Electrophoretic Deposition to shape the source particle material into a finished magnet geometry. The source particle material is dispersed in a liquid so that the particles can move freely. Electric fields in the shape of the finished product then draw the particles to the desired location to form a “green body”, much like an unfired…

Image

LLNL researchers have designed and tested performance characteristics for a multichannel pyrometer that works in the NIR from 1200 to 2000 nm. A single datapoint without averaging can be acquired in 14 microseconds (sampling rate of 70,000/s). In conjunction with a diamond anvil cell, the system still works down to about 830K.

Image

LLNL researchers have developed a broadband heterodyne detection system that incorporates several significant improvements that move the state of the art toward quantum noise limited performance. The design comprises of an optical element that increases the intensity of the incoming light on the detector by a factor exceeding 50x. It is based on the properties of surface plasmons in…

Image

The LLNL method is based on freeze‐casting of aerosolized and pressurized metal salt solutions and subsequent thermal processing. This method generates both porous particles with sizes down to one micron and macroscopic monoliths with nanometer scale ligaments/struts. The material's density can be controlled during the freeze‐dried stage. Compared to conventional approaches, this method…

Image

LLNL has developed a system and method that accomplishes volumetric fabrication by applying computed tomography (CT) techniques in reverse, fabricating structures by exposing a photopolymer resin volume from multiple angles, updating the light field at each angle. The necessary light fields are spatially and/or temporally multiplexed, such that their summed energy dose in a target resin volume…

Image

SERPENTINE AND CORDUROY CIRCUITS TO ENHANCE THE STRETCHABILITY OF A STRETCHABLE ELECTRONIC DEVICE (IL11169, US Patents 7,265,298 and 7,871,661)

STRETCHABLE POLYMER-BASED ELECTRONIC DEVICE (IL11206, US Patent…

Image
Adhesive Actuated Insertion Shank

RIGID STIFFENER-REINFORCED FLEXIBLE NEURAL PROBES, AND METHODS OF FABRICATION USING WICKING CHANNEL-DISTRIBUTED ADHESIVES AND TISSUE INSERTION AND EXTRACTION (IL12469, US Patent Application US2014/0378993)

This invention is superior to silicon based…

Image

DEPOSITING BULK OR MICRO-SCALE ELECTRONICS (IL12387, US Patent 9,485,873 and US patent Application US2017/0013713)

This invention provides thicker electrodes on microelectronic devices using thermo-compression bonding…

Image

SENSOR ARRAY AND APPARATUS FOR SIMULTANEOUS OBSERVATION OF TISSUE ELECTROPHYSIOLOGY, CONTRACTILITY, AND GROWTH (IL13165, Pending US patent application)

Cardiac toxicity is one of the major causes of drug candidate failure in clinical studies and is responsible for the failure in regulatory approval of drugs as well as the retraction of numerous drugs from the market. Critical to the…

Image

MULTI-ELECTRODE NEURAL PROTHESIS SYSTEM (IL12575, US Patent Application US2016/0030753)

This invention entails a hermetically sealed electronics package of a multi-electrode neural prosthesis system, where the sealed enclosure communicates with external components via feedthroughs. The feedthrough…

Image

HIGH DENSITY POLYMER-BASED INTEGRATED ELECTRODE ARRAY (IL11207, US Patent 7,035,692)

This invention is a high-density polymer-based integrated electrode apparatus that comprises a central electrode body and multiple arms extending from the electrode body. The central electrode body with multiple arms is…

Image

IMPLANTABLE NEUROMODULATION SYSTEM FOR CLOSED-LOOP STIMULATION AND RECORDING SIMULTANEOUSLY AT MULTIPLE BRAIN SITES (IL13065; PCT Application WO2017100649)

This technology relates to a modular system for deep brain stimulation (DBS) and electrocorticography (ECoG). The system has an implantable…

Image

LLNL researchers have developed a method in which a sleeveless photonic crystal optical fiber cane can be fabricated. A set of glass canes and capillaries, doped or un-doped, are stacked into a hexagonal pre-form. A piece of outer tube which is much shorter than the pre-form, but longer than the "hot zone" of a draw tower furnace, is placed around the pre-form on either end, and crimped to the…

Image

The OneID solution combines custom-developed code with proven commercial software to provide three core components; (1) back-end processes and administrative utilities to reconcile identity data received from multiple partners within an organization into a single unique identifier; (2) an interface that dynamically displays authentication options to the user based on the assurance level…

Image

Monolithic Telescopes are a novel implementation of a solid catadioptric design form, instantiated in a monolithic block of fused silica.

Image
Livermore researchers have developed a method of fabricating functional polymer-based particles by crosslinking UV-curable polymer drops in mid-air and collecting crosslinked particles in a solid container, a liquid suspension, or an air flow. Particles could contain different phases in the form or layered structures that contain one to multiple cores, or structures that are blended with…
Image

LLNL has developed a new method for securely processing protected data on HPC systems with minimal impact on the existing HPC operations and execution environment. It can be used with no alterations to traditional HPC operations and can be managed locally. It is fully compatible with traditional (unencrypted) processing and can run other jobs, unencrypted or not, on the cluster simultaneously…

Image

LLNL has developed a reference electrode that is a great improvement on the widely used silver or platinum wire QRE commonly used in electrochemistry in ionic liquids. This new reference electrode, based on a silver-sulfide coated silver wire, exhibits greatly improved stability over a QRE. The stability of our RE approaches that of the Ag/Ag+ RE, but unlike the Ag/Ag+ RE, the RE reported here…

Image

LLNL has developed specific technical approaches and methods to obtain proteomic information from various human tissue types (hair, skin, teeth, bone). These processes have been developed to maximize proteomic information recovery using liquid chromatography/mass spectrometry methods. LLNL has also developed software tools and processes to mine genetic databases and human genetic sequence data…

Image

Researchers at LLNL have developed a novel method to express and purify significant quantities of AMPs. AMP is fused to the N-terminus of a self-assembling protein called encapsulin from Thermotoga maritima, which forms protein cages with 60 monomer units. N-terminal fusion of the peptide to encapsulin results in encapsulation of the peptide within the protein cage, which prevents cytotoxicity…

Image

Customized for industrial uses, the ALE3D4I code allows a user to not only switch between the Lagrangian and Eulerian techniques but also combine the two so that the mesh “relaxes” at the leading edge of the object. The amount of relaxation is determined by the user, who can “weight” the simulation so that more zones are forced into a specific area of interest, for greater accuracy at that…

Image
ParaDiS, or Parallel Dislocation Simulator, is a simulation tool that performs direct numerical simulation of dislocation ensembles, the carriers of plasticity, to predict the strength in crystalline materials from the fundamental physics of defect motion, evolution, and interaction.
Image

LLNL has a patented process to produce colloidal silica directly from geothermal fluids. Livermore’s process uses membranes to produce a mono-dispense slurry of colloidal silica particles for which there are several applications. LLNL has demonstrated that colloidal silica solutions that result from extraction of silica from geothermal fluids undergo a transition to a solid gel over a range of…

Image

LLNL has developed a liquid-free method that increases the overall mechanical resistance of self-supported, carbon nanotube assemblies through nanoscale reinforcement by gas-phase deposition of a thermally cross-linkable polymer. Polymer-reinforcement increases the strength of CNT yarns after crosslinking. For example, a minimal amount (<200 nm) of poly-glycidyl metacrylate (PGMA) deposited…

Image

The LLNL charged particle deposition technology enables fabrication of material via the charged particle induced dissociation of precursor molecules. For the case electron beam induced fabrication of boron carbide, gaseous boron precursor is delivered to a substrate in a vacuum chamber. Surface adsorbed molecules are dissociated by a beam of electrons. Non-volatile fragments remain on the…

Image

LLNL has solved the challenges of depth-resolved parallel TPL by using a temporal focusing technique in addition to the spatial focusing technique used in serial writing systems. We temporally focus the beam (through optical set-up design) so that a sharp Z-plane can be resolved while projecting 2D “light sheets” that cause localized photo-polymerization. This enables printing of complex 3D…

Image

The LLNL method for optimizing as built optical designs uses insights from perturbed optical system theory and reformulates perturbation of optical performance in terms of double Zernikes, which can be calculated analytically rather than by tracing thousands of rays. A new theory of compensation is enabled by the use of double Zernikes which allows the performance degradation of a perturbed…

Image

LLNL has developed an optically clear iodine-doped resist that increases the mean atomic number of the part. AM parts fabricated with this resist appear radio-opaque due to an increase in the X-ray attenuation by a factor of 10 to 20 times. Optical clarity is required so that the photons can penetrate the liquid to initiate polymerization and radio opacity is required to enable 3D computed…

Image

LLNL's method of equivalent time sampling incorporates an embedded system that generates the pulses used to trigger the external circuit and the data acquisition (DAQ). This removes the external reference clock, allowing the overall system clock rate to change based on the ability of the embedded system. The time delays needed to create the time stepping for equivalent time sampling is done by…

Image

There are three main components to the RaFTS system: 1) the radiation detector, which can be of any type and from any manufacturer; 2) the RaFTS electronics, which produce the electronic pulses that are injected into the electronics of the radiation detector through a (to be) standardized port interface; and 3) the exercise scenario, which defines the synthetic radiation field and time-varying…

Image

By combining 3D printing and dealloying., researchers at LLNL have developed a method for fabricating metal foams with engineered hierarchical architectures consisting of pores at least 3 distinct length scales. LLNL’s method uses direct ink writing (DIW), a 3D printing technique for additive manufacturing to fabricate hierarchical nanoporous metal foams with deterministically controlled 3D…

Image

Simrev is a python library imported into a user-generated program. As the program grows in capability and complexity, the engineered product matures. The "software twin" handles all changes to product configuration and is the portal to running supercomputing analysis and managing workflow for engineering simulation codes. Assemblies become program modules; parts, materials, boundary conditions…

Image

LLNL researchers have developed an alternative route to protective breathable membranes called Second Skin technology, which has transformative potential for protective garments. These membranes are expected to be particularly effective in mitigating physiological burden.

For additional information see article in Advanced Materials…

Image

LLNL Polyelectrolyte Enabled Liftoff (PEEL), is used to fabricate freestanding polymer films as thin as 10 nm that are capable of bearing loads ranging from milligrams to grams and deformations of up to forty percent (40%). PEEL employs robust, water-based, and self-optimizing surface chemistry to fabricate ultrathin films greater than 100 cm2 in area. The process is easily scalable in size…

Image

The novel LLNL technique uses electric fields to drive and control assembly. In the literature such methods have heretofore only formed disordered ensembles. This innovative method increases local nanocrystal concentration, initiating nucleation and growth into ordered superlattices. Nanocrystals remain solvated and mobile throughout the process, allowing fast fabrication of ordered…

Image

As diode pumped solid state lasers (DPSSL) become more common there is a need to drive these pump diode arrays in a compact, efficient and cost-effective manner. The LLNL system for controlling high current laser diode arrays is an integrated system for meeting the needs of driving laser diode arrays in a DPSSL. The system is comprised of technologies required to control the DPSSL that…

Image

LLNL researchers have developed a process and direct ink writing (DIW) inks for fabricating structured carbon aerogels. This approach gives control over channel size and geometries of organic and carbon aerogels. The 3D printed Resorcinol-Formaldehyde (RF) ink structures are activated to yield high surface area carbon aerogels.

Image

LLNL has developed a new active memory data reorganization engine. In the simplest case, data can be reorganized within the memory system to present a new view of the data. The new view may be a subset or a rearrangement of the original data. As an example, an array of structures might be more efficiently accessed by a CPU as a structure of arrays. Active memory can assemble an alternative…

Image

LLNL has developed several MLD grating technologies that extend the state of the art in overall laser optical power handling capability. LLNL MLD grating optics are the convolution of the following key technologies:

  1. Optical coating designs utilizing >100 thin film layers - enables ultra-low-loss, ppm transmission levels through the coating, high diffraction efficiency, and…
Image

LLNL researchers have demonstrated a novel single-shot recording technology for transient optical signals in a time regime of picoseconds to nanoseconds for which currently there is a significant instrumentation gap.

The optical switching capability of optical semiconductors can be exploited in a pump-probe style architecture, where an auxiliary pump beam is crossed through the signal…

Image
LLNL researchers have developed a system that relies on machine learning to monitor microfluidic devices. The system includes (at least) a microfluidic device, sensor(s), and a local network computer. The system could also include a camera that takes real-time images of channel(s) within an operating microfluidic device. A subset of these images can be used to train/teach a machine learning…
Image
This technology uses AM printing methods applied to explosives materials. But unlike producing explosives parts, the explosive component is added at a low concentration of around 4 to 6 wt. %. This allows for the final form, to be labeled as a non-hazardous material. A suitable matrix (substrate) is selected that ultimately will be non-volatile (reducing improper training on contaminants) and…
Image

LLNL researchers have developed a method for fabricating active or passive optical glass components, non-optical glass components, and/or glass sensors with custom material composition profiles in 1-, 2-, or 3-dimensions. In this method, DIW additive manufacturing technique is used to print filaments of a rheologically-tuned ink--containing a glass forming species--into a loosely bound,…

Image

LLNL researchers have conceived and performed studies relevant to the development of AM powders synthesized from asteroidal or meteoritical sources and the use of the powder as the feed source for additive manufacturing systems deployed in space. The method includes the steps of locating an asteroid or meteorite, making contact with the asteroid or meteorite, harvesting material from the…

Image

Livermore Laboratory researchers have developed a methodology for degradation of TBP using an inexpensive, readily available, and environmentally friendly salt, potassium iodide (KI), in a similarly inexpensive, abundant, and green solvent dimethylsulfoxide (DMSO) to efficiently convert TBP to the potassium salts of dibutylphosphate (DBP) and monobutylphosphate (MBP) The reaction is carried…

Image

LLNL researchers have developed a new method of separating copper nanowires from copper nanoparticles in a two-phase liquid system, within one step, within a few minutes and with excellent separation results.

LLNL's new method of separation is based on the unique observation that copper nanowires can cross the interface between water and a wide range of hydrophobic organic solvent (e…

Image

Lawrence Livermore researchers are the first to successfully develop a practical fiber-optic amplifier that generates significant optical gain from 1,390 nanometers (nm) to 1,460 nm with relatively good efficiency. This discovery enables the potential for installed optical fibers to operate in an untapped spectral region known as the E-band, in addition to the C- and L-bands where they…

Image

LLNL researchers have developed a high-speed, tightly-packed array of micro-mirrors capable of rapidly (>40 kHz) directing light over large angles (>10°) in two axes-tip and tilt-with continuous closed-loop motion control.

LLNL's TTP micro-mirror array design contains a number of unique features that enable its high performance. These features are generated from the application…

Image

Lawrence Livermore researchers have developed a novel waveguide with resonant leakage elements that frustrate guidance at well-defined and selectable wavelengths. Based on this waveguide, the LLNL team has fabricated a Large Mode Area Neodymium doped fiber with suppression of the four-level transition around 1060 nm, and demonstrated lasing on the three-level transition at 930 nm with good…

Image

The core innovation of LLNL's enzyme-embedded, multi-component polymer-based bioreactors perform one or more additional functions of the bioreactor:

  • efficient distribution of reactants and removal of products
  • exposure of enzymes to high concentrations of gas-phase reactants
  • separation of products and reactants
  • formation of high surface area…
Image

LLNL’s IUC system protects electronic systems from tampering and protects the electronic system’s components from unauthorized use. This is directly aimed at solving known issues in cybersecurity and electronic device counterfeiting.

LLNL’s IUC system can be programmed to enable a variety of responses at a component level and at the device level if verification of the authenticity…

Image

LLNL computational scientists have developed a new technology that solves critical problems for combustion engineers and designers. LLNL’s Zero-Order Reaction Kinetics (Zero-RK) is a software package for simulating chemically reacting systems. Zero-RK’s algorithms dramatically reduce the time to results for many commercial applications, providing in some cases a three-orders-of-magnitude…

IPO logo over a face profile with interconnected lines

Autonomous systems operate in the air, on land, and even underwater. Sensing and avoiding objects is a critical necessity for autonomous vehicles when navigating their environment. Detecting objects in a vehicle's path and rapidly computing changes to the vehicle's trajectory requires object detection, path optimization, and vehicle guidance. Current solutions to this problem using optics can…

Image

LLNL researchers have developed a novel method of 3D printing regular microstructured architectures and subsequent complex macrostructures from additively manufactured bio-based composite thermoset shape memory polymer composite materials. This technology for 3D additively manufactured parts utilizes up to a 4 axis control DIW system for fabricating bio­ based thermally cured epoxy based SMP…

Image

LLNL’s Polyelectrolyte Enabled Liftoff (PEEL) process makes changes to the substrate preparation, the holder and liftoff technique, and suggests modifications to the material itself to enable the preparation of large ultrathin free-standing films.

PEEL enables ultrathin films by chemically modifying the deposition substrate and decreasing the interfacial energy so that even thin films…

Image

LLNL researchers have developed the hardware and chemistry to allow additive manufacturing of short carbon fibers in a thermoset polymer matrix which have a high degree of structural alignment over conventional cast or pressed short/chopped carbon fiber polymer composites.

The invention is based on the shear dispersal, alignment and concentration of fiber fraction within a resin…

Image

LLNL’s invention for non-destructive evaluation of water ingress in photovoltaic modules uses a non-invasive optical detection technique based on hyperspectral near infrared imaging technology with frequencies tuned to water absorption band. In this way a quantitative 2D image of the water content in a given device can be obtained remotely and repeatedly over time. A key challenge is presented…

Image
“NUFT (Nonisothermal, Unsaturated Flow and Transport) is a 3D multi-phase non-isothermal flow and transport model for both saturated and unsaturated simulations. It has been extensively applied to groundwater cleanup (especially thermal alternatives), deep geologic processes, including high level nuclear waste repositories and subsurface sequestration of carbon dioxide.”
Image

Covalent cross-linking of graphene sheets is achieved by using carbon nanoparticles as cross-linker for randomly oriented single layered graphene oxide nanoplatelets. The use of a covalently integrated carbon binder makes these graphene aerogel foams mechanically very robust, and allows one to achieve high bulk electrical conductivities even at low densities.

Image

Conventional membranes tend to be two dimensional and with relatively large thickness, which limit the achievable permeability. The ultimate goal in membrane technologies is to combine high permeability and high selectivity. LLNL has developed a transformational 3D nm-thick membrane structure using ALD (atomic layer deposition) template approach. Our membrane structure has two independent…

Image

LLNL’s Forensic Science Center (FSC) is currently the only facility in the United States that is accredited to accept samples and analyze them for the possible presence of chemical weapons under the Chemical Weapons Convention. FSC scientists are global experts in chemical, nuclear, and biological counterterrorism and their work leads to innovative tools and therapies with biosecurity and…

Image

LLNL’s Optically-based Interstory Drift Meter System provides a means to accurately measure the dynamic interstory drift of a vibrating building (or other structure) during earthquake shaking. This technology addresses many of the shortcomings associated with traditional strong motion accelerometer based building monitoring.

LLNL’s discrete diode position sensitive device is a newly…

Image

3D printing involves the layer-by-layer deposition of one, or more, materials. The spatial placement of the material, if carefully controlled, can influence a desired static or dynamic property. The use of 3D printing to build complex and unique energetic components is at the center of LLNL’s architected energetic materials and structures effort. LLNL has developed several different methods…

Image

This approach harvests both mechanical and thermal energy by combining nanowires and phase change materials. These devices were fabricated on Kapton® polyamide films and used ZnO nanowires with the same growth direction to assure alignment of the piezoelectric potentials of all of the wires. The circuit was designed as long, parallel electrode arrays perpendicular to the nanowire axis. Good-…

IPO logo over a face profile with interconnected lines

LLNL’s polymer/carbon composites exhibit a strong temperature dependent conductivity response. Below a critical temperature such as the glass transition temperature ( Tg) or melting temperature, Tm of the polymeric network, the composite material is electrically insulating, having measured conductivities in the range of 1E-10 S cm-1. Upon being heated through a phase transition, the…

Image

LLNL has developed a new class of nitrogenous ligands for metals and their complexes chosen for their known propensity to chelate metal ions. Further chemical modifications of this scaffold were performed to furnish a novel series of ligands that are capable of coordinating different metal ions.

Image

LLNL has developed a method for electroplating nickel oxide/hydroxide electrode materials with very high energy- and power density onto a current collector. The method is especially suitable for coating porous current collectors with high surface areas.

Image

LLNL has developed a new system, called the Segmentation Ensembles System, that provides a simple and general way to fuse high-level and low-level information and leads to a substantial increase in overall performance of digital image analysis. LLNL researchers have demonstrated the effectiveness of the approach on applications ranging from automatic threat detection for airport security, to…

Image

LLNL’s carbon nanotube trans-membrane channels invention is a new class of nanopores that combines the best features of all three existing types of pores while substantially mitigating a number of shortcomings exhibited by each of these types of pores.

The method involves sonication of nanotube in presence of lipids, including but not limited to DOPC or DPhPC. One advantage of this…

Image

LLNL researchers have developed an acoustofluidic device design consisting of a silicon and glass chip bonded to a piezoelectric plate. The acoustic microfluidic chip design is optimized using numerical modelling for maximal pressure standing wave amplitude, and its unique configuration with subdivided channels enables high-throughput operation and customized placement of the acoustic pressure…

Image

This invention suggests to reduce the noise in Q-bits and other low-noise electronic and superconducting devises devices by synthesizing special materials where several classes of fluctuators (two-level systems) are excluded (or, their number is substantially reduced) both in the volume of materials and on the boundaries and interfaces. This invention also suggests materials with low number of…

Image

LLNL has developed a brain-on-a-chip system with a removable cell-seeding funnel to simultaneously localize neurons from various brain regions in an anatomically relevant manner and over specific electrode regions of a MEA. LLNL’s novel, removable cell seeding funnel uses a combination of 3D printing and microfabrication that allows neurons from select brain regions to easily be seeded into…

Image

LLNL scientists have developed a new metal additive manufacturing technique that uses diode lasers in conjunction with a programmable mask to generate 2D patterns of energy at the powder surface. The method can produce entire layers in a single laser shot, rather than producing layers spot by spot as is currently done in powder bed fusion methods.

Image

A key element of this invention is the recognition that all life-important chemical interaction is situated in the mid-to-far infrared energy range. LLNL’s Infrared (IR) Photon-Sensitive Spectromicroscopy invention is a system designed to suppress thermal radiation background and to allow IR single photon-sensitive spectromicroscopy of small samples by using absorption, reflection, and…

Image

LLNL researchers are developing a battery-powered molecular diagnostic (MDx) platform for biothreat and public health agent identification. LLNL researchers developed isothermal molecular diagnostic assays to detect and identify DNA from pathogenic bacteria, including E. coli, known to cause UTI’s and sepsis. Detection of the bacterial DNA does not require technically challenging DNA isolation…

Image
Antennas are a foundational component of our global communication and information systems. Cell phones, Wi-Fi networks, and satellite links couldn’t exist without them. LLNL scientists, Gerald Burke, Andrew Poggio, and Edward Miller created the Numerical Electromagnetic Code (NEC), an antenna modeling system for wire and surface antennas. As computer capability to handle heavy calculations…
Image

LLNL’s system consists of one or more flashlamp-pumped Nd:glass zig-zag amplifiers, a very low threshold stimulated-Brillouin-scattering (SBS) phase conjugator system, and a free-running single frequency Nd:YLF master oscillator.

Image

The VITA-D personal biodosimeter technology is designed to measure the vitamin D synthetic capacity of sunlight and/or artificial ultraviolet radiation in-situ, using the same photochemical process from which vitamin D3 is synthesized in human skin.

The innovators envision two embodiments of this technology:

  • Polymer films are doped with molecules of pro-vitamin D and are…
Image

LLNL’s technology does not use battery-powered tags. Rather it uses a tag technology that has the same range characteristics of battery-powered tags (approximately 10 m) but without the conventional battery.

Image

GuardDog technology uses ultra-wideband (UWB) impulse sensors (also known as micropower impulse radar or MIR), optional global positioning systems (GPS), local signal processing, and user-selectable (power and bandwidth) radio frequency (RF) communication transceivers. UWB sensors emit and detect very-low-amplitude and short-voltage impulses for detecting returning radar signals. By employing…

Image

The HERMES bridge inspector is an ultrawideband-based nondestructive evaluation (NDE) system. The LLNL-developed system provides 3-D ground penetrating radar information. An array of micropower impulse radar (MIR) sensors is mounted under a trailer. Reflected radar data is gathered by driving the trailer over a bridge at 55 mph and 3-D image maps of the internal structure of the bridge deck…

Image

An invention at LLNL uses a mixture of solid and liquid dielectric media. This combination has properties that are an improvement over either separately. The solid phase, in the form of small pellets, inhibits fluid motion, which reduces leakage currents, while the liquid phase (dielectric oil) provides self-repair capabilities. Also, since the media is removable, the high voltage equipment…

Image

Transparent ceramic fabrication allows the production of gadolinium- , lutetium-, and terbium-based garnets which are difficult to grow by melt techniques due to phase instabilities. Phase stabilization of the garnets is accomplished by the addition of the intersubstitutional ions, Gallium and/or Scandium.

Scientists have developed many versatile and scaleable fabrication methods.…

Image

An LLNL and UCLA team has recently demonstrated a new compound material that can directly convert thermal energy to electrical energy. Basic research is required before this newly invented material can be produced in the form of a thin film and tested at high frequency. The team is interested in partnering with a company from basic research and development through production of a manufacturing…

Image

LLNL researchers have combined a novel approach or using bioinformatics with cell-free expression to identify and characterize a class of proteins that kill Gram-positive bacteria with extremely high specificity. The class of proteins is collectively known as muramidases and possess bacterial lytic activity. Muramidases generally represent a potential class of novel antimicrobials for use…

Image

LLNL researchers have grown and characterized scintillator crystals of Strontium Iodide (SrI2). Scintillator energy resolution and light yield proportionality surpass NaI and are similar to LaBr3. The SrI2 scintillators doped with europium (Eu) exhibit very high light yields (> 100,000 photons/MeV), extremely good energy resolution (<3% at 662 keV) and excellent light yield…

Image

LLNL's X-ray spectrometers based on STJ have been developed for high-resolution soft X-ray spectroscopy. STJ consist of two superconducting thin film electrodes separated by a thin insulating tunnel barrier. They measure X-ray energies from the increase in tunneling current after X-ray absorption in one of the electrodes excites additional charge carriers above the superconducting energy gap.…

Image

LLNL is developing the Space-based Telescopes for Actionable Refinement of Ephemeris (STARE). STARE is a constellation of low cost nano-satellites (less than 5Kg) in low-earth orbit dedicated to the observation of space debris in conjunction with a ground-based infrastructure for maintenance, coordination and data processing. Each nano-satellite in the constellation is capable of recording an…

Image

LLNL has identified solution-grown organic crystals having scintillation efficiency not only close to, but even exceeding that of stilbene.. LLNL's invention relates to a new class of neutron detectors based on scintillation response of organic single crystals. More specifically, the use of organic molecules grown from solution and to molecules including the basic benzene or phenyl structure…

Image

This technology provides algorithms that accurately localize small-arm-fire by tracking bullets from high-powered weapons, automatic rifles, rocket propelled grenades (RPGs), mortars, and similar projectiles. The software integrates commercially available infrared video cameras, processes raw imagery data, detects and tracks projectiles, and determines the location of the shooters within…

Image

LLNL's Slurry Stabilization Method provides a chemical means of stabilizing a polishing compound in suspension at working concentrations without reducing the rate of material removal. The treated product remains stable for many months in storage.

Image

The SLIDER deflector includes a waveguide, a serrated mask positioned above the waveguide cladding, and a synchronized pump beam. The pump beam illuminates the serrated mask with a short pulse and transfers its pattern to the guiding layer where it imprints a sequence of prisms. The prisms are activated via nonlinear optical effects in the semiconductor and persist for the duration of the…

Image

The technology that is available has the capability to inject realistic radiation detection spectra into the amplifier of a radiation detector and produce the all the observables that are available with that radiation detection instrument; count-rate, spectrum, dose rate, etc.

The system uses the capability of LLNL to generate the source output for virtually any source and determine…

Image

Lawrence Livermore National Laboratory scientists have developed a signal enhancing microchip apparatus and method that enhances a microfluidic detector's limits by magnetically focusing the target analytes in a zone of optical convergence. In summary, samples are associated with magnetic nanoparticles or magnetic polystyrene coated beads and moved down the flow channels until they are trapped…

Image

LLNL offers opportunities for joint software development to bridge the gap between the capabilities of Independent Software Vendors (ISVs) of scientific and engineering application codes and HPC users’ needs. Successful relations will yield a greater number of commercial codes available to run on HPC platforms, software with expanded features and improved performance, and wider availability…

Image

LLNL’s BioBriefcase is a compact and portable instrument capable of autonomously detecting the full spectrum of bioagents, including bacteria, viruses and toxins in the air. It uses the state of art technologies to collect, process, and analyze samples to detect, and identify genetic and protein signatures of bioagents.

Image

Scientists at Lawrence Livermore National Laboratory have developed a plastic that can detect neutrons, something previously thought impossible.

Livermore scientists demonstrated a plastic scintillator that can discriminate between neutrons and gamma rays with a polyvinyltoluene (PVT) polymer matrix loaded with a scintillating dye, 2,5-diphenyloxazole (PPO). They have found that…

Image

This technology uses either of two X-ray wave-front sensor techniques, Hartmann sensing and two-dimensional shear interferometry, both of which are capable of measuring the entire two-dimensional electric field, both the amplitude and the phase, with a single measurement. Capturing both the absorption and phase coefficients of the index of refraction can help to reconstruct the image.…

Image

LLNL's multi-well plate cover penetration system is an array cutting and tape folding tool, based on 96-well, 384-well, and 1536-well geometries, that can be robotically operated and will cut, open, and fold inward the sealing tape so that samples can be subsequently aspirated without the need for human intervention to remove the seal which is an aerosol generating and contaminating process…

Image

The Optical Transconductance Varistor (Opticondistor) overcomes depletion region voltage limitations by optically exciting wide bandgap materials in a compact package. A 100μ thick crystal could have the capability approaching 40kV and would replace numerous equivalent junction devices. Thus, unlike present junction transistors or diodes, this wide bandgap device can be…

Image

The invention relates to a measurement method and system for capturing both the amplitude and phase temporal profile of a transient waveform or a selected number of consecutive waveforms having bandwidths of up to about 10 THz in a single shot or in a high repetition rate mode. The invention consists of an optical preprocessor which can then output a time-scaled replica of the input signal to…

Image

LLNL researchers have combined Raman and infrared (IR) spectroscopy methods in a single device. The sensor is able to detect, identify, and quantify a range of unknown gases. Raman spectroscopy records the degree of light scattered while IR measures the amount of light that is absorbed. The combination of the two techniques results in complementary spectra that serve as molecular-level…

Image

LLNL seeks partners interested in developing and commercializing any or all of these and additional processes for its project as fits the partner's business interest. Examples of novel processing and resultant materials are described below.

High Explosive Consolidation (HEC) is conducted in a unique facility in Georgia that permits the explosive consolidation of powders at temperatures…

Image

LLNL is interested in developing a universal platform for the delivery and presentation of any protein antigen, including toxin, viral and bacterial proteins, with apparent concomitant adjuvant activity to enhance the host immune response.

Image

In collaboration with USDA, LLNL has developed and tested in vitro (or ex vivo) production of natural rubber polymer by using NLP-stabilized rubber transferase.

Image

LLNL's neutron "Pillar Detector" fabrication technology uses semiconductor-based micro-structured elements as an electrical signal generation medium for the detection of neutrons. These materials in the form of semiconductor "pillars" embedded in matrix of high cross-section neutron converter materials (such as Boron) that emit charged particles upon interaction with neutrons. These charged…

Image

LLNL's NeMS system enables network mapping operations by using two LLNL-developed software systems: LLNL's NeMS tool and the Everest visualization system. Each software system can be also used separately for their specific applications. When the two systems are used together as an iterative analysis platform, LLNL's NeMS system provides network security managers and information technology…

Image

Chemical and biological sensors based on nanowire or nanotube technologies exhibit observable ultrasensitive detection limits due to their unusually large surface-to-volume architecture. This suggests that nanosensors can provide a distinct advantage over conventional designs. This advantage is further enhanced when the nanosensor can harvest its meager power requirements from the surrounding…

Image
LLNL's new EMB designs are intended to answer to all of the new requirements for bulk energy storage systems, including very low parasitic losses and high turnaround efficiency. The new systems are designed for low capital and maintenance cost, and long (decades) service lifetime. The size of the modules will be such as to make them useful in a wide variety of applications, all the way from…
Image

LLNL has developed a technology that provides near-instantaneous heating of aqueous samples in microfluidic devices. The method heats samples in a focused area within a microfluidic channel on miniaturized chips. The microwave heating device is composed of a waveguide or microstrip transmission line embedded in a microfluidic channel. Aqueous solution microwave heating allows extremely fast…

Image

The technology is an outgrowth of the world's fastest solid-state digitizer, which was designed to measure sub-nanosecond events generated by fusion experiments on the Laboratory's Nova laser. MIR is based on the radiation of short voltage impulses that are reflected off nearby objects and detected by MIR's extremely high-speed sampling receiver. Prototype units emit one million impulses per…

Image

The biotech industry aims to move towards an on-chip system for sample generation, amplification and detection of both DNA and RNA based organisms. LLNL has invented a new way of isolating samples in a system.

This invention enables creation of partitioned fluid "packets" between polymeric sheets for chemical separation, DNA amplification or PCR-based DNA detection. The polymeric…

Image

LLNL has developed a compact and low-power cantilever-based sensor array, which has been used to detect various vapor-phase analytes. For further information on the latest developments, see the article "Sniffing the Air with an Electronic Nose."

Image

Lawrence Livermore National Laboratory’s scientists have developed the Lawrence Livermore Microbial Detection Array (LLMDA), a technology enabling detection of bacteria, viruses and other organisms. This technology has shown value for applications in detection for product safety, diagnostics and bioterrorism events.

LLMDA contains probes fitted onto a one-inch by three-inch glass…

Image

The nanosphere synthesis process works when a nanostructured substrate is heated above a critical temperature in the presence of a small amount of metal on the nanostructured surface. The metal acts as a particular type of catalyst for nanowire formation. It is periodically segregated within the nanowire in a thermodynamically well-defined process as nanowires grow. The result is…

Image
Livermore materials scientists and engineers are designing and building new materials that will open up new spaces on many Ashby material selection charts, such as those for stiffness and density as well as thermal expansion and stiffness. This is being accomplished with unique design algorithms and research into the additive manufacturing techniques of projection microstereolithography, direct…
Image

Redox ion-exchange polymers ("redox-ionites") and membranes possessing cation- and anion- exchange, amphoteric, complex-forming and oxidation-reduction abilities have been developed on the basis of the biocompatible synthetic and chemically modified natural polymers. In addition, developments have been made towards methods of obtaining of water-soluble and spatially cross-linked ionites of…

Image

The LLNL detector measures radiation over a large dynamic range, spanning both high hazardous levels and weak levels, including natural background radiation. In weak radiation fields, the detector also measures gamma-ray spectra. The cost of the detector is significantly less than the total cost of existing separate detectors that could perform the same measurements.

Image

Using various excitation wavelengths, a hyperspectral microscope takes advantage of autofluorescence and polarized light scattering from cellular components to obtain composite images that highlight their presence. The light collection efficiency is maximized to achieve image acquisition times and rates suitable for in vivo applications.

Image

The patented intracranial hematoma detection technology uses Micropower Impulse Radar (MIR). MIR uses short, high frequency electromagnetic pulses to obtain information in a non-invasive manner. Unlike ultrasound and other electromagnetic techniques, MIR can operate well through the skull, which is of great importance for intracerebral as well as epidural and subdural hematomas. The MIR…

Image

The Forensic Science Center at LLNL has invented a portable, compact and rugged hydrogen peroxide vapor generator. The system produces a consistent concentration of hydrogen peroxide vapor. The hydrogen peroxide vapor is generated from a safe and easy to maintain source of aqueous hydrogen peroxide and produces a dynamic flow stream at discrete concentrations.

Image

This technology comprises a method of depositing coatings of dissimilar materials on a substrate. A laser pulse hits the film of deposited material covered by a thin water layer. The laser deposition on the water-material interface generates huge pressure accelerating film to the velocities a few hundred meters per second. The film hits the substrate at an oblique angle. The high velocity of…

Image

LLNL has developed a noble gas mass spectrometry facility that houses a state-of-the-art water-gas separation manifold and mass spectrometry system designed specifically for high throughput of groundwater samples. The fully automated, computer-controlled manifold system allows analysis of the full suite of noble gases (3He/4He, He, Ne, Ar, Kr, and Xe concentrations), along with low level…

Image

LLNL has developed a wide band (WB) ground penetrating radar (GPR) technology to detect and image buried objects under a moving vehicle. Efficient and high performance processing algorithms reconstruct images of buried or hidden objects in two or three dimensions under a scanning array. The technology includes a mobile high-performance computing system allowing GPR array sensor data to be…

Image

LLNL has developed a radiation detector that cools to operating temperatures in 1-2 hours using two separate cooling stages. The first cooling brings the instrument to operating temperature. The embedded second cooling system achieves portable detection that can be sustained for 8-12 hours.

In addition, an integrated, hermetically-sealed package has been developed complete with…

Image

This technology is an extremely small and robust cell in which a very small volume of gas is sampled, while maintaining high sensitivity and specificity, by combining it with:

  • Highly tunable and commercially available semiconductor lasers, such as edge emitting lasers and vertical cavity surface emitting lasers (to provide various absorption lines of one specie and to capture…
Image

The selected industrial partner and LLNL will enter into a Cooperative Research and Development Agreement (CRADA) to develop the next generation of laser technologies for MEGa-ray systems and to create a next generation of MEGa-ray sources that could be marketed to both the industrial and academic communities.

The MEGa-ray system developed will be based on LLNL's proprietary, multi-…

Image

LLNL scientists have developed an approach for full spectrum analysis during gamma ray spectrometry using a spectral library signature created from a large amount of spectral data. The signature can be compared to unknown spectral measurements for the identification of previously unknown nuclear material.

Image

LLNL has developed an innovative technology known as flow-through electrode capacitive desalination (FTE-CD) that promises to unlock an almost inexhaustible water source for U.S. and global population markets. FTE-CD represents a robust and low-maintenance path for efficiently and cost-effectively producing clean drinking water from seawater and brackish water.

FTE-CD removes salt by…

Image

LLNL's invention uses energy efficient diode arrays for softening metals and alloys to enable friction stir process and friction stir welding. The use of intense light from compact, light-weight, and energy-efficient diode arrays to preheat the material being processed to the softening point eliminates defects associated with insufficient weld temperature such as tunnel voids.

The…

Image

LLNL scientists have developed a simple neutron detection technique that can discriminate fissile material from non-fissile material. A low cost digital data acquisition unit collects data at high rates and processes large volumes of data in real-time. This technique functions in a passive mode much like a standard portal monitor. There are options for converting the technique to an active…

Image

To overcome limitations with cellular silicone foams, LLNL innovators have developed a new 3D energy absorbing material with tailored/engineered bulk-scale properties. The energy absorbing material has 3D patterned architectures specially designed for specific energy absorbing properties. The combination of LLNL's capabilities in advanced modeling and simulation and the additive…

Image

The design calculations that have been performed in exploring the potentialities of LLNL's new approaches to flywheel energy storage have been built on existing and past LLNL flywheel programs, including a program aimed at flywheel systems for the bulk storage of electricity at utility scale. To achieve the requirements of such systems, as mentioned above, LLNL has developed some key new…

Image

This electrostatic (E-S) generator/motor operates through the time-variation of the capacity of an electrically charged condenser to generate AC voltages and/or mechanical torque. The output of the generator is such that it can take advantage of the development of high-voltage solid-state electronic components now coming into wide use in the electrical utilities.

Image

The LLNL approach uses both the electric and magnetic components of an electromagnetic wave, which provides information about the direction of wave emanation as well as the flux of energy in the wave. This new, potentially portable technology is intended to identify and locate low-frequency electromagnetic noise sources in order to take off-line or quickly isolate and repair the interfering…

Image

The new LLNL technology would sense active control or other signals from the grid and automatically shed or re-establish load as appropriate. This gradual reduction and reestablishment of load would give operators more time to reconfigure grid resources to respond to the transient. This increased time window for reaction should lead to lower operating costs with the current grid architecture…

Image

The Discriminant Random Forest combines advantages of several methodologies and techniques to produce lower classification error rates.

Image

The invention utilizes the statistical nature of radiation transport as well as modern processing techniques to implement a physics-based, sequential statistical processor. By this we mean that instead of accumulating a pulse-height spectrum as is done in many other systems, each photon is processed individually upon arrival and then discarded. As each photon arrives, a decision is…

Image

The new LLNL technique works by transiently removing and trapping concrete or rock surface material, so that contaminants are confined in a manner that is easy to isolate and remove. Our studies suggest that 10 m2 of surface could be processed per hour. The technique easily scales to more surface/hr.

Image

LLNL is developing a highly-sensitive compact Compton imaging technology with excellent energy resolution, good imaging performance and large field-of-view. This system is built of large-volume and high-resolution Si(Li) and HPGe detectors. These detectors are built in double-sided strip configurations providing excellent three-dimensional position resolution. The system can measure individual…

Image

Dubbed the "LLNL Chemical Prism", the LLNL system has use wherever there is a need to separate components of a fluid. A few examples include:

  • Chemical detection for known and previously unknown chemicals or substances
  • Separation of biomolecules from a cellular extract
  • Fractionation of a complex mixture of hydrocarbons
  • Forensic analysis of…
Image

A ceramic HEPA filter designed to meet commercial and DOE requirements, as well as to minimize upgrade installation logistics for use in existing facilities. Current key performance requirements are described in DOE Standard 3020. The ceramic filter is designed to be nonflammable, corrosion resistant, and compatible with high temperatures and moisture. The ceramic filter will significantly…

Image

LLNL has developed a novel process of production, isolation, characterization, and functional re-constitution of membrane-associated proteins in a single step. In addition, LLNL has developed a colorimetric assay that indicates production, correct folding, and incorporation of bR into soluble nanolipoprotein particles (NLPs).

LLNL has developed an approach, for formation of NLP/…

Image

LLNL scientists have developed a radiation detection network that uses solid state detectors (e.g. CZT) coupled to cellular telephones. Detection of gamma and/or neutron radiation is possible with high sensitivity. A network of cellular phones GPS locations and their detection data can be correlated for real-time analysis of potential nuclear threats.

Image

LLNL's new "Catalyst" supercomputer is now available for collaborative projects with American industry. Developed by a partnership with Cray and Intel, the novel architecture behind this high performance computing (HPC) cluster is intended to serve as a proving ground for new HPC and Big Data technologies and algorithms.

Catalyst boasts nearly a terabyte of addressable memory per…

Image

LLNL has developed a new method of separating carbon dioxide from flue gas. LLNL's ion pump method increases the concentration of dissolved carbonate ion solution. This increases the vapor pressure of carbon dioxide gas, permitting carbon dioxide to be removed from the downstream side of the ion pump as a pure gas. The ion pumping may be obtained from reverse osmosis, electrodialysis, or the…

Image

LLNL's high fidelity hydrocode is capable of predicting blast loads and directly coupling those loads to structures to predict a mechanical response. By combining this code and our expertise in modeling blast-structure interaction and damage, along with our access to experimental data and testing facilities, we can contribute to the design of protective equipment that can better mitigate the…

Image

A select number of intracellular pathogens persist naturally in some amoebas and their cysts. LLNL has invented a technology that exploits this process to use amoeba cysts as natural containers for portable transport and long term storage. In addition, this novel encystment system incorporates sample purification and enrichment for clinical samples, taken in the hospital, lab, or any natural…

Image

The invention is a new tool for Homeland Security and Department of Defense efforts to reduce or eliminate potential personal exposure to terrorist-related biological and "dirty bomb" weapon particulates. This will assist emergency responders and aid in protecting public health. This copolymer and solvent solution is used to bind with airborne hazardous particulates, such as biological weapon…

Image

Nanomaterials that are emerging out of cutting edge nanotechnology research are a key component for an energy revolution. Carbon-based nanomaterials are ushering in the "new carbon age" with carbon nanotubes, nanoporous carbons, and graphene nanosheets that will prove necessary to provide sustainable energy applications that lessen our dependence on fossil fuels.

Carbon aerogels (CAs)…

Image
This technology uses microelectromechanical systems (MEMS), adaptive optics (AO), and optical coherence tomography (OCT) to produce 3-D retina images at the cellular level. AO compensates for optical aberrations by continuously sampling images, and rapidly compensating for these aberrations via a wavefront corrector. MEMS reduce the size and cost of the system without sacrificing speed or…
Image

LLNL has developed novel nanoporous carbon materials for the surface-stress-induced actuator technology. The morphology of these materials has been designed to combine high surface area and mechanical strength. The process allows for the fabrication of large monolithic pieces with low densities and high structural integrity. One actuation technology relies on electrochemically- induced changes…